1460-47-5

Downstream Products

• 1460-47-5 (+)-cyclobutylmandelic acid 
• 1460-47-5 (-)-cyclobutylmandelic acid 
• 185030-05-1 N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-hydroxy-2-phenylacetamide 
• 257603-54-6 methyl 2-cyclobutyl-2-methoxy-2-phenylacetate 
• 257603-51-3 N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide 
• 257603-52-4 N-methyl-N-(1-tert-butyloxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-trimethylsiloxy-2-phenylacetamide 
• 257603-50-2 N-[1-(3-ethoxycarbonylpropyl)piperidin-4-yl]-2-cyclobutyl-2-hydroxy-2-phenylacetamide 

Relevant academic research and scientific papers

Arylacetic amide derivative or salt thereof, and pharmaceutical comprising it

Described is an arylacetic amide derivative represented by the following formula (1): wherein R1 represents an aryl group or the like, R2 and R3 each independently represents an alkyl group, a cycloalkyl group or the like, and R4 represents an aralkyl gro

1,4-di-substituted piperidine derivatives

This invention provides novel 1,4-di-substituted piperidine derivatives of the general formula ?I! STR1 and the pharmaceutically acceptable salts thereof, wherein: Ar represents a phenyl group or a five- or six-membered heteroaromatic group having one or two hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom in which one or two optional hydrogen atoms on the ring may be replaced by substituent groups selected from the group consisting of a halogen atom and a lower alkyl group; R1 represents a cycloalkyl group of 3 to 6 carbon atoms or a cycloalkenyl group of 3 to 6 carbon atoms; R2 represents a saturated or unsaturated aliphatic hydrocarbon radical of 5 to 15 carbon atoms; and X represents O or NH. These compounds have selective antagonistic activity against the muscarinic M3 receptors and can hence be used safely with a minimum of side effects.

Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds

Oxybutynin chloride [4-(diethylamino)-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate hydrochloride, Ditropan] is widely used for the relief of symptoms in neurogenic bladder. This is a result of its combined anticholinergic, antispasmodic, and local anesthetic activities. In a study directed toward development of agents possessing the beneficial properties of oxybutynin, but having a longer duration of action, a series of metabolically more stable keto analogues of the parent ester, i.e. substituted 7-amino-1-hydroxy-5-heptyn-2-ones along with some analogues and derivatives, was prepared and evaluated for in vitro and in vivo antimuscarinic action in guinea pig preparations. Several members of the series were potent antimuscarinics having a longer duration of activity than that of oxybutynin in a guinea pig cystometrogram model. On the basis of its in vitro and in vivo antimuscarinic activity, coupled with a 5-fold greater duration of action than that of oxybutynin, 1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenyl-5-heptyn-2-one (14b) was selected for clinical evaluation.