185099-48-3Relevant academic research and scientific papers
Anticonvulsant and anxiolytic lactam and thiolactam derivatives
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, (2008/06/13)
This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.
Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3- benzyl-2-piperidinones (δ-valerolactams) and hexahydro-2H-azepin-2-ones (ε- caprolactams)
Reddy, P. Amruta,Woodward, Karen E.,McIlheran, Sarah M.,Hsiang, Bonnie C. H.,Latifi, Tammy N.,Hill, Matthew W.,Rothman, Steven M.,Ferrendelli, James A.,Covey, Douglas F.
, p. 44 - 49 (2007/10/03)
A series of 3-substituted 2-piperidinone (δ-valerolactam) and hexahydro-2H-azepin-2-one (ε-caprolactam) derivatives were prepared and evaluated as anticonvulsants in mice. In the 2-piperidinone series, 3,3- diethyl compound 7b is the most effective antico
