3768-43-2

Basic information

• Product Name: 3-METHYLPIPERIDIN-2-ONE
• Synonyms: 3-METHYLPIPERIDIN-2-ONE;3-Methyl-2-piperidinone;2-piperidinone, 3-methyl-;3-Methyl-2-oxopiperidine
• CAS NO: 3768-43-2
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.16
• EINECS: 223-196-1
• Product Categories: Pyrans, Piperidines & Piperazines
• Mol File: 3768-43-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 64-65
• Boiling Point: 211.9°C (rough estimate)
• Flash Point: 138.6°C
• Appearance: /
• Density: 1.0223 (rough estimate)
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: 1.4580 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-METHYLPIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLPIPERIDIN-2-ONE(3768-43-2)
• EPA Substance Registry System: 3-METHYLPIPERIDIN-2-ONE(3768-43-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 3768-43-2(Hazardous Substances Data)

Usage

General Description

3-Methylpiperidin-2-one is a chemical compound with the molecular formula C6H11NO. It is a cyclic amide derivative of piperidinone, with a methyl group substituted at the 3-position of the piperidine ring. 3-METHYLPIPERIDIN-2-ONE has applications in the pharmaceutical industry, particularly as a precursor in the synthesis of other chemical compounds. It may also be used as a building block for the development of bioactive molecules or as a reagent in organic synthesis. 3-Methylpiperidin-2-one is a colorless liquid at room temperature and may be used as a solvent in various chemical reactions. Its properties and reactivity make it a valuable intermediate in the production of a wide range of chemical products.

InChI:InChI=1/C6H11NO/c1-5-3-2-4-7-6(5)8/h5H,2-4H2,1H3,(H,7,8)

Upstream product

• 10483-16-6 5-amino-2-methyl-valeric acid 
• 67-56-1 methanol 
• 14660-52-7 ethyl 5-bromovalerate 
• 89896-39-9 ethyl 5-azidovalerate 
• 128773-73-9 N-(4-Methoxybenzyl)-δ-valerolactam 
• 3430-17-9 2-bromo-3-picoline 
• 356789-19-0 ethyl (trans)-5-[(t-butoxycarbonyl)amino]-2-methyl-2-pentenoate 
• 37672-46-1 3-methyl-1-(phenylmethyl)-2-piperidinone 
• 29553-51-3 3-methyl-piperidine-2,6-dione 
• 179685-56-4 1-Aza-2-methoxy-3-methyl-1-cyclohexene 
• 5693-62-9 2,3,4,5-tetrahydro-6-methoxypyridine 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 64-17-5 ethanol 
• 626-56-2 3-Methylpiperidine 

Downstream Products

• 150989-48-3 C₂₀H₂₃NO₂S 
• 1690-76-2 1,3-dimethyl-2-piperidinone 
• 105-60-2 caprolactam 
• 185099-48-3 1,3-diphenylmethyl-3-methyl-2-piperidinone 
• 185099-47-2 3-ethyl-3-methyl-1-phenylmethyl-2-piperidinone 
• 37672-46-1 3-methyl-1-(phenylmethyl)-2-piperidinone 
• 23789-83-5 3,3-Dimethyl-2(1H)-piperidinone 

Relevant articles and documents

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ-Lactams

Metal-catalyzed hydrogenation is an effective method to transform readily available arenes into saturated motifs, however, current hydrogenation strategies are limited to the formation of C?H and N?H bonds. The stepwise addition of hydrogen yields reactive unsaturated intermediates that are rapidly reduced. In contrast, the interruption of complete hydrogenation by further functionalization of unsaturated intermediates offers great potential for increasing chemical complexity in a single reaction step. Overcoming the tenet of full reduction in arene hydrogenation has been seldom demonstrated. In this work we report the synthesis of sought-after, enantioenriched δ-lactams from oxazolidinone-substituted pyridines and water by an interrupted hydrogenation mechanism.

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3- dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlogumine; and use of the derivatives and analogs for treating cancer.

Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C-N Bond Formation from Nonactivated Aliphatic Carboxylic Acids

Copper-catalyzed directed decarboxylative amination of nonactivated aliphatic carboxylic acids is described. This intramolecular C-N bond formation reaction provides efficient access to the synthesis of pyrrolidine and piperidine derivatives as well as the modification of complex natural products. Moreover, this reaction presents excellent site-selectivity in the C-N bond formation step through the use of directing group. Our work can be considered as a big step toward controllable radical decarboxylative carbon-heteroatom cross-coupling.