Anti aldol reactions of α-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin

Article abstract of DOI:10.1016/0040-4039(96)01879-5

The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4 → 15.