185246-17-7

Basic information

• Product Name: 2-Chloromethyloxazole
• Synonyms: OXAZOLE, 2-(CHLOROMETHYL)-;2-CHLOROMETHYL-OXAZOLE;2-(Chloromethyl)-1,3-oxazole
• CAS NO: 185246-17-7
• Molecular Formula: C₄H₄ClNO
• Molecular Weight: 117.53
• Mol File: 185246-17-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 143.505 °C at 760 mmHg
• Flash Point: 40.591 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 6.681mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Store at -20°C
• PKA: 0.37±0.10(Predicted)
• CAS DataBase Reference: 2-Chloromethyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloromethyloxazole(185246-17-7)
• EPA Substance Registry System: 2-Chloromethyloxazole(185246-17-7)

Safety Data

• Hazardous Substances Data: 185246-17-7(Hazardous Substances Data)

Usage

General Description

2-Chloromethyloxazole is a chemical compound that belongs to a class of organic compounds known as aromatic heterocyclic compounds. These are compounds that contain a heteroatom in a planar system, making them aromatic. The chemical has a molecular formula of C4H4ClNO. In terms of its physical properties, this substance is relatively stable but should be stored in a cool, dry place. As of now, 2-Chloromethyloxazole is mainly used for research and not much information is available about its toxicity or ecological impact.

InChI:InChI=1/C4H4ClNO/c5-3-4-6-1-2-7-4/h1-2H,3H2

Upstream product

• 288-36-8 1,2,3-triazole 
• 79-04-9 chloroacetyl chloride 
• 130551-92-7 (1,3-oxazol-2-yl)methanol 

Downstream Products

• 1235840-46-6 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoro-methyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile hydrochloride 
• 1458656-62-6 methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-(oxazol-2-ylmethoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 
• 1415235-41-4 tert-butyl 4-(4-fluorophenyl)-2-(oxazol-2-ylmethyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate 
• 1315462-65-7 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride 
• 1235840-48-8 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile 
• 1024582-75-9 tert-butyl 5-(2-(3-(oxazol-2-ylmethoxy)phenyl)-quinazolin-4-ylamino)-1H-indazole-1-carboxylate 

Relevant articles and documents

Preparation method of 2-oxazolylmethylamine heterocyclic compound

The invention relates to a preparation method of a 2-oxazolylmethylamine heterocyclic compound. The preparation method comprises the following steps: reacting 1H-1,2,3-triazole with chloroacetyl chloride under the action of DIPEA, and carrying out heating for conversion into 2-chloromethyloxazole; adding a product of the previous step into a reaction system of di-tert-butyl iminodicarboxylate andsodium hydride in batches to form 2-[(di-tert-butyloxycarbonylamino)methyl]oxazole; and dissolving 2-[(di-tert-butyloxycarbonylamino)methyl]oxazole in a methanol solution of hydrogen chloride, carrying out concentration after a complete of reaction, adding methyl tert-butyl ether, and performing filtering and drying to obtain the 2-oxazolylmethylamine heterocyclic compound. The invention providesan effective process route for preparing the 2-oxazolylmethylamine heterocyclic compound.

HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).