185246-17-7

Usage

Uses

Used in Research Applications:
2-Chloromethyloxazole is used as a research chemical for the investigation of its properties and potential applications in various scientific fields. Its aromatic heterocyclic nature makes it a valuable compound for studying the effects of heteroatoms on the aromaticity and stability of organic compounds. Additionally, it may be employed in the synthesis of more complex molecules or as a building block in the development of new materials or pharmaceuticals.

InChI:InChI=1/C4H4ClNO/c5-3-4-6-1-2-7-4/h1-2H,3H2

Upstream product

• 130551-92-7 (1,3-oxazol-2-yl)methanol 
• 288-36-8 1,2,3-triazole 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1024582-75-9 tert-butyl 5-(2-(3-(oxazol-2-ylmethoxy)phenyl)-quinazolin-4-ylamino)-1H-indazole-1-carboxylate 
• 1235840-48-8 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile 
• 1235840-46-6 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoro-methyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile hydrochloride 
• 1315462-65-7 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride 
• 1415235-41-4 tert-butyl 4-(4-fluorophenyl)-2-(oxazol-2-ylmethyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate 
• 1458656-62-6 methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-(oxazol-2-ylmethoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 

Relevant academic research and scientific papers

Preparation method of 2-oxazolylmethylamine heterocyclic compound

The invention relates to a preparation method of a 2-oxazolylmethylamine heterocyclic compound. The preparation method comprises the following steps: reacting 1H-1,2,3-triazole with chloroacetyl chloride under the action of DIPEA, and carrying out heating for conversion into 2-chloromethyloxazole; adding a product of the previous step into a reaction system of di-tert-butyl iminodicarboxylate andsodium hydride in batches to form 2-[(di-tert-butyloxycarbonylamino)methyl]oxazole; and dissolving 2-[(di-tert-butyloxycarbonylamino)methyl]oxazole in a methanol solution of hydrogen chloride, carrying out concentration after a complete of reaction, adding methyl tert-butyl ether, and performing filtering and drying to obtain the 2-oxazolylmethylamine heterocyclic compound. The invention providesan effective process route for preparing the 2-oxazolylmethylamine heterocyclic compound.

ANTI-BACTERIAL COMPOUNDS

A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).

4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER

A quinazoline derivative of the Formula I: wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blood