18529-12-9

Basic information

• Product Name: 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE
• Synonyms: 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE;2-chloro-6-fluoro-4-methylquinoline(SALTDATA: FREE)
• CAS NO: 18529-12-9
• Molecular Formula: C10H7ClFN
• Molecular Weight: 195.62
• Mol File: 18529-12-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 296°C at 760 mmHg
• Flash Point: 132.8°C
• Appearance: /
• Density: 1.311g/cm³
• Vapor Pressure: 0.0026mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE(18529-12-9)
• EPA Substance Registry System: 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE(18529-12-9)

Safety Data

• Hazardous Substances Data: 18529-12-9(Hazardous Substances Data)

Usage

General Description

2-CHLORO-6-FLUORO-4-METHYLQUINOLINE is a chemical compound with the molecular formula C10H7ClFN. It is a quinoline derivative with a chlorine atom at the 2-position, a fluorine atom at the 6-position, and a methyl group at the 4-position of the quinoline ring. 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE has potential applications in the pharmaceutical industry, as it possesses antimicrobial and antimalarial properties. Its unique structure makes it a valuable building block for the synthesis of various pharmaceutical agents and bioactive molecules. Additionally, it may also be used as an intermediate in the production of agrochemicals and other specialty chemicals. Overall, 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE is a versatile chemical that has relevance in drug discovery and development as well as in the field of agrochemistry.

InChI:InChI=1/C10H7ClFN/c1-6-4-10(11)13-9-3-2-7(12)5-8(6)9/h2-5H,1H3

Upstream product

• 15912-69-3 6-fluoro-2-hydroxy-4-methylquinoline 
• 371-40-4 4-fluoroaniline 
• 2713-85-1 N-(4-fluorophenyl)-3-oxobutanamide 

Downstream Products

• 108099-80-5 6-fluoro-2-hydrazino-4-methylquinoline 
• 109274-62-6 [1-(6-Fluoro-4-methyl-quinolin-2-yl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid 

Relevant articles and documents

Compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds

The invention provides 7-substituted-5-methyl-1,2,4-triazolo[4,3-a] quinoline and 7-substituted-5-ethoxy-[1,2,4]-triazolo[4,3-a] quinoline compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds in the field of preparing anticonvulsion medicines.

Anti-mutagenic structural modification by fluorine-substitution in highly mutagenic 4-methylquinoline derivatives

We have previously shown that fluorine-substitution at position 3 of quinoline deprived this molecule of mutagenicity, possibly due to interference with the yield of its metabolically activated form, the 1,4-hydrated 2,3-epoxide (enamine epoxide), which is directly responsible for the mutagenic modification of DNA. To further explore the possibility of a method for anti-mutagenic modification of mutagens by fluorine-substitution, 4-methylquinoline (4-MeQ), the most mutagenic form of all the quinoline derivatives examined so far, was used as a target in the present study. Five mono- and di-fluorinated derivatives of 4-MeQ, 2-fluoro-4-methylquinoline (2-F-4-MeQ), 6-F-4-MeQ, 7-F-4-MeQ, 2,6-difluoro-4-methylquinoline (2,6-diF-4-MeQ), and 2,7-diF-4-MeQ, were subjected to analysis of their structure-mutagenicity relationships. The 2-fluorinated derivatives (2-F-4-MeQ, 2,6-diF-4-MeQ, and 2,7-diF-4-MeQ) were all non-mutagenic in the Ames test. 7-F-4-MeQ was as highly mutagenic as, and 6-F-4-MeQ was less mutagenic than non-fluorinated 4-MeQ. Metabolic studies were also conducted with 4-MeQ, 2-F-4-MeQ, 6-F-4-MeQ, and 7-F-4-MeQ, using a liver microsomal enzyme fraction prepared from the 3-methylcholanthrene-treated rat. The HPLC analytical data showed that, although the metabolic patterns (hydroxylation at 4-methyl group as a main metabolic pathway and 3-hydroxylation as a minor pathway) of these four F-MeQs were similar to one another, only the 3-hydroxy metabolite of 2-F-4-MeQ was not produced under the present experimental conditions employed. These results suggest that fluorine-substitution at position 2 of 4-MeQ inhibited the formation of the enamine epoxide in the pyridine moiety and deprived this molecule of mutagenicity as in the case of quinoline. Copyright (C) 2000 Elsevier Science B.V.