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Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2,4-DIFLUOROBENZOYLACETATE is used as a synthetic intermediate for the production of various pharmaceuticals. Its reactivity allows for the creation of diverse functional groups, which are essential in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2,4-DIFLUOROBENZOYLACETATE is utilized as a key intermediate in the synthesis of pesticides and other agrochemicals. Its ability to form different chemical structures contributes to the development of effective products for agricultural use.
Used as a Flavoring Agent in Food and Beverage Industry:
METHYL 2,4-DIFLUOROBENZOYLACETATE is employed as a flavoring agent to impart or modify the taste of food and beverages. Its slightly sweet smell and ability to blend well with other ingredients make it a valuable addition in enhancing the sensory experience of consumable products.

Upstream product

• 1583-58-0 2,4-difluoro-benzoic acid 
• 38330-80-2 monomethyl monopotassium malonate 
• 72482-64-5 2,4-difluorobenzoyl chloride 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 

Downstream Products

• 1439357-01-3 methyl 1-cyclpropyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-02-4 methyl 7-fluoro-1-isopropyl-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-03-5 methyl 1-allyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-04-6 methyl 1-butyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-05-7 methyl 1-benzyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-06-8 methyl 1-cyclohexyl-7-fluoro-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-08-0 methyl 7-fluoro-4-oxo-2-phenyl-4H-chromene-3-carboxylate 
• 1439357-09-1 methyl 7-fluoro-4-oxo-2-p-tolyl-4H-chromene-3-carboxylate 
• 1439357-10-4 methyl 7-fluoro-2-(4-fluorophenyl)-4-oxo-4H-chromene-3-carboxylate 
• 1439357-12-6 methyl 2-(2,3-dimethoxyphenyl)-7-fluoro-4-oxo-4H-chromene-3-carboxylate 
• 1439357-13-7 methyl 7-fluoro-2-(3-nitrophenyl)-4-oxo-4H-chromene-3-carboxylate 
• 1439356-61-2 methyl 7-fluoro-1-methyl-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate 
• 1439357-11-5 methyl 2-(4-chlorophenyl)-7-fluoro-4-oxo-4H-chromene-3-carboxylate 
• 500187-56-4 2-(2,6-dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives

A novel one-pot synthesis of the 2-substituted 3-carboxy-4-quinolone/ chromone derivatives from readily available 3-oxo-3-arylpropanoates and amides/acyl chlorides is reported, without any transition metal aid. The Royal Society of Chemistry 2013.

Synthesis of β-keto esters by carbonylation of halomethylketones

A number of β-keto esters were synthesized by Pd-catalyzed carbonylation of halomethylketones in the presence of tributylamine in 68-86percent yields. The reaction is completed in 2 hours at 110°C and 10 bar CO pressure. Chloromethylketones are carbonylated selectively while 2-bromoacetophenone is partly reduced to acetophenone as a byproduct. The reaction can be carried out at atmospheric pressure though the rate stays low. The reaction mechanism is discussed.