185333-02-2Relevant academic research and scientific papers
First synthesis of enantiomerically pure primary helical spirocycles based on the repetitive addition of lithiated methoxyallene to chiral 3(2H)-dihydrofuranone derivatives
Hormuth, Stephan,Schade, Wolfgang,Reissig, Hans-Ulrich
, p. 2001 - 2006 (1996)
Repetitive additions to chiral 3(2H)-dihydrofuranones opened a route to the first enantiomerically pure primary helical spirocyclic compounds. Thus, addition of lithiated methoxyallene 2 to furanone 9 provided adduct 10 with excellent diastereoselectivity
