First synthesis of enantiomerically pure primary helical spirocycles based on the repetitive addition of lithiated methoxyallene to chiral 3(2H)-dihydrofuranone derivatives

Article abstract of DOI:10.1002/jlac.199619961209

Repetitive additions to chiral 3(2H)-dihydrofuranones opened a route to the first enantiomerically pure primary helical spirocyclic compounds. Thus, addition of lithiated methoxyallene 2 to furanone 9 provided adduct 10 with excellent diastereoselectivity