185434-43-9

Basic information

• Product Name: 4-Piperidineacetic acid, 1-[(3,4-dichlorophenyl)methyl]-, ethyl ester
• CAS NO: 185434-43-9
• Molecular Formula: C16H21Cl2NO2
• Molecular Weight: 330.254
• Mol File: 185434-43-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-Piperidineacetic acid, 1-[(3,4-dichlorophenyl)methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidineacetic acid, 1-[(3,4-dichlorophenyl)methyl]-, ethyl ester(185434-43-9)
• EPA Substance Registry System: 4-Piperidineacetic acid, 1-[(3,4-dichlorophenyl)methyl]-, ethyl ester(185434-43-9)

Safety Data

• Hazardous Substances Data: 185434-43-9(Hazardous Substances Data)

Upstream product

• 41661-47-6 piperidin-4-one 
• 102879-50-5 ethyl 4-pyridylacetate hydrochloride 
• 220772-52-1 1-(3,4-dichlorobenzyl)-4-piperidone 
• 18880-04-1 3,4-dichlorobenzyl bromide 
• 220772-53-2 ethyl [1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 

Downstream Products

• 220772-54-3 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropanol 
• 220772-55-4 1-[1-(3,4-dichlorobenzyl)piperidin-4-yl]-3-methyl-2-butanone 
• 220772-56-5 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine 
• 185434-48-4 2-[1-(3,4-Dichloro-benzyl)-piperidin-4-yl]-ethanol 
• 617714-42-8 C₁₄H₁₇Cl₂NO 

Relevant articles and documents

Design and synthesis of novel CCR3 antagonists

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.

Cyclic amine derivatives- CCR-3 receptor antagonists

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.