220772-55-4

Upstream product

• 220772-53-2 ethyl [1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate 
• 220772-52-1 1-(3,4-dichlorobenzyl)-4-piperidone 
• 185434-43-9 ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate 
• 18880-04-1 3,4-dichlorobenzyl bromide 
• 41661-47-6 piperidin-4-one 

Relevant academic research and scientific papers

Design and synthesis of novel CCR3 antagonists

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC50 of 0.0082 μM in the binding assay and 0.0024 μM in the chemotaxis assay.