185434-98-4Relevant academic research and scientific papers
Diastereoselective synthesis of an isoprostane: (±)-8-epi-PGF(2α) ethyl ester
Taber,Herr,Gleave
, p. 194 - 198 (2007/10/03)
A total synthesis of the isoprostane (±)-8-epi-PGF(2α) ethyl ester (5) is described, based on the diastereoselective cyclization of α-diazo ketone 7. This ketone is assembled by aldol condensation between α-diazo ketone 8 and aldehyde 9. The sequential α-diazo ketone aldol/insertion described here offers a powerful new approach to cycloalkane construction.
