185436-24-2Relevant academic research and scientific papers
Lipase-mediated resolution of cis-1-amino-2-indanol, the key component of the HIV protease inhibitor indinavir
Anilkumar,Goto, Kouhei,Takahashi, Tomiki,Ishizaki, Kozo,Kaga, Harumi
, p. 2501 - 2503 (1999)
The efficient and direct resolution of cis-1-amino-2-indanol using Candida antarctica lipase B catalyzing the alcoholysis of its N,O-diacetyl derivative is reported.
Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation
Kim, Yoon-Jung,Choi, Yong-Sung,Yang, Sai,Yang, Woo Ram,Jeong, Jin-Hyun
supporting information, p. 1981 - 1984 (2015/09/01)
Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.
PREPARATION OF HYDROXY COMPOUNDS BY BIOCONVERSION WITH DIOXYGENASE
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, (2008/06/13)
PCT No. PCT/GB96/01208 Sec. 371 Date Nov. 21, 1997 Sec. 102(e) Date Nov. 21, 1997 PCT Filed May 20, 1996 PCT Pub. No. WO96/37628 PCT Pub. Date Nov. 28, 1996A process for preparing a compound of Formula (3) in which R2 is -H; which comprises the steps: i) conversion of a compound of Formula (1) into a compound of Formula (2) using a dioxygenase enzyme; ii) conversion of the compound of Formula (2) into a compound of Formula (3) wherein is -COR; and iii) conversion of the compound of Formula (3) in which R2 is -COR into a compound of Formula (3) in which R2 is -H; wherein R2, a, b, c, d, Z, m and X are as defined in claim 1. Also claimed are individual steps of the process and new compounds of Formula (2).
Scandium trifluoromethanesulfonate-catalyzed cleavage of esters bearing a coordinative group at a vicinal position
Kajiro, Hiroshi,Mitamura, Shuichi,Mori, Atsunori,Hiyama, Tamejiro
, p. 1553 - 1560 (2007/10/03)
Scandium trifluoromethanesulfonate is found to be a Lewis acid catalyst for selective cleavage of esters containing a coordinative group adjacent to an ester moiety. The reaction proceeds under weak acidic conditions at room temperature; the catalyst can be recovered and reused. Even α-acyloxy ketones are deacetylated without racemization. Selective monodeacetylation at C-10 of paclitaxel has been achieved.
