185461-73-8

Upstream product

• 110720-45-1 (3S,4R,5S)-4-(tert-butoxycarbonylamino)-3-(tert-butyldimethylsiloxy)-5-methylheptanoic acid 
• 185518-64-3 (S)-1-[(S)-2-((S)-4-Hydroxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 185518-25-6 (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 185515-75-7 (S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoic acid benzyl ester 

Downstream Products

• 185461-56-7 Boc-Thr[Z-N(Me)-O(Me)-Tyr]-Ist-Hip-Leu-Pro-OBzl 
• 185461-51-2 Boc-didemnin A 
• 185461-57-8 C₄₇H₇₅N₅O₁₄ 
• 137219-37-5 dehydrodidemnin B 
• 185461-52-3 C₄₇H₇₃N₅O₁₃ 
• 120286-04-6 (5S,8S,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-15-((S)-sec-butyl)-14-hydroxy-5-isobutyl-10-isopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone 

Relevant academic research and scientific papers

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d