185518-25-6

Basic information

• Product Name: (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester
• Synonyms: (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester
• CAS NO: 185518-25-6
• Molecular Weight: 588.86
• Mol File: 185518-25-6.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester(185518-25-6)
• EPA Substance Registry System: (S)-1-{(S)-2-[(S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester(185518-25-6)

Safety Data

• Hazardous Substances Data: 185518-25-6(Hazardous Substances Data)

Upstream product

• 185515-75-7 (S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,5-dimethyl-3-oxo-hexanoic acid benzyl ester 

Downstream Products

• 185461-56-7 Boc-Thr[Z-N(Me)-O(Me)-Tyr]-Ist-Hip-Leu-Pro-OBzl 
• 185461-51-2 Boc-didemnin A 
• 185461-57-8 C₄₇H₇₅N₅O₁₄ 
• 185461-73-8 (S)-1-((S)-2-{(S)-4-[(3S,4R,5S)-4-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-5-methyl-heptanoyloxy]-2,5-dimethyl-3-oxo-hexanoylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 137219-37-5 dehydrodidemnin B 
• 185461-52-3 C₄₇H₇₃N₅O₁₃ 
• 120286-04-6 (5S,8S,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-15-((S)-sec-butyl)-14-hydroxy-5-isobutyl-10-isopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone 
• 185518-64-3 (S)-1-[(S)-2-((S)-4-Hydroxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant articles and documents

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d