185461-51-2Relevant articles and documents
Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution
Jou, Gemma,Gonzalez, Isabel,Albericio, Fernando,Lloyd-Williams, Paul,Giralt, Ernest
, p. 354 - 366 (2007/10/03)
New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d