185462-75-3

Upstream product

• 185462-74-2 (1R,2S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid ethyl ester 
• 75-65-0 tert-butyl alcohol 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 185838-02-2 (4R)-4-(phenylmethoxymethyl)-1,3,2-dioxathiolane 2,2-dioxide 
• 185462-73-1 (S)-2-Benzyloxymethyl-cyclopropane-1,1-dicarboxylic acid diethyl ester 
• 100-39-0 benzyl bromide 
• 14347-83-2 (R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane 

Downstream Products

• 1616599-52-0 (1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2-(hydroxymethyl)-2'-isopropyl-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride 
• 1616599-53-1 (1S,2S)-N-(2,4-difluorobenzyl)-9'-hydroxy-2'-isopropyl-2-(methoxymethyl)-1',8'-dioxo-1',2',3',8'-tetrahydrospiro[cyclopropane-1,4'-pyrido[1,2-a]pyrazine]-7'-carboxamide hydrochloride 

Relevant academic research and scientific papers

SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR

Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present invention relates to a compound represented by the following formula [I] or [II] or a pharmace

Large scale synthesis of N-protected 2,3-methanomethionine stereoisomers

Three stereoisomers of N-protected forms of 2,3-methanomethionine (cyclopropyl derivatives of methionine, or 'cyclo-Met') were prepared. Two of the syntheses developed involved diol (S)-1, which was more easily obtained from L-gulono-1,4-lactone than via juxtaposition of the benzyl protection of (R)-1. The cis-cyclo-Met derivative (cis refers to the orientation of the side chain relative to the amino functionality), FMOC-(2R,3S)-cyclo-Met, was obtained via a route based on a previous synthesis of (2R,3S)-cyclo-Met from the lactone 3, but the protected trans-cyclo-Met, BOC-(2S,3S)-cyclo-Met, was obtained via an improved procedure that does not involve lactone 3.