185525-96-6Relevant articles and documents
The synthesis and activity of spiroindane growth hormone secretagogues
Tata, James R.,Nargund, Ravi P.,Murphy, Marcia M.,Johnston, David B. R.,Patchett, Arthur A.,Cheng, Kang,Wei, Liente,Chan, Wanda W.-S.,Butler, Bridget,Jacks, Thomas M.,Hickey, Gerard,Smith, Roy
, p. 663 - 668 (2007/10/03)
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.