180465-55-8

Basic information

• Product Name: SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE
• Synonyms: SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE;Spiro[1H-indene-1,4'-piperidine]-3(2H)-one;Spiro[1H-indene-1,4'-piperidin]-3(2H)-one;Spiro[indene-1,4'-piperidin]-3(2H)
• CAS NO: 180465-55-8
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.27
• Mol File: 180465-55-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE(180465-55-8)
• EPA Substance Registry System: SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE(180465-55-8)

Safety Data

• Hazardous Substances Data: 180465-55-8(Hazardous Substances Data)

Usage

General Description

SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE is a chemical compound that belongs to the class of spiro compounds, which are characterized by the presence of two fused rings that share a single common atom. This particular compound contains an indene ring fused to a piperidine ring, with a ketone functional group attached to the spiro carbon atom. It exhibits potential pharmacological properties and has been studied for its potential use in drug discovery and development. Its unique structure and potential biological activities make it an interesting target for further research in the field of medicinal chemistry.

Upstream product

• 159634-59-0 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 
• 6163-66-2 2,2'-oxybis(2-methyl-propane) 
• 100-39-0 benzyl bromide 
• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 

Downstream Products

• 185525-94-4 C₂₈H₃₄N₂O₅ 
• 917898-66-9 1-neopentyl-1'-(2-nitrophenyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline] 
• 159634-63-6 Spiro(2-oxo-1,2,3,4-tetrahydroquinoline-4,4'-piperidine) 
• 209280-12-6 1'-(3-((S)-(3-chlorophenyl))-4-(N-(phenylsulfonyl)(methyl-amino))-butyl)-spiro(indan-1-one-3,4'-piperidine) 
• 855849-88-6 1'-[trans-3-(4-chlorophenyl)allyl]spiro[indan-1-one-3,4'-piperidine] 
• 185525-96-6 C₃₂H₄₁N₃O₆ 
• 185526-08-3 C₃₃H₄₃N₃O₅ 
• 185525-95-5 C₂₃H₂₆N₂O₃ 
• 878167-49-8 benzyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

Conformationally constrained ortho- Anilino diaryl ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl) -3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist

Preclinical antithrombotic efficacy and bleeding models have demonstrated that P2Y1 antagonists are efficacious as antiplatelet agents and may offer a safety advantage over P2Y12 antagonists in terms of reduced bleeding liabilities. In this article, we describe the structural modification of the tert-butyl phenoxy portion of lead compound 1 and the subsequent discovery of a novel series of conformationally constrained ortho-anilino diaryl ureas. In particular, spiropiperidine indoline-substituted diaryl ureas are described as potent, orally bioavailable small-molecule P2Y1 antagonists with improved activity in functional assays and improved oral bioavailability in rats. Homology modeling and rat PK/PD studies on benchmark compound 3l will also be presented. Compound 3l was our first P2Y1 antagonist to demonstrate a robust oral antithrombotic effect with mild bleeding liability in the rat thrombosis and hemostasis models.

Modulators of muscarinic receptors

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions

The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.