185526-08-3

Basic information

• Product Name: Carbamic acid, [2-[[1-[(2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]- 4-phenylbutyl]amino]-1,1-dimethyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R)-
• CAS NO: 185526-08-3
• Molecular Formula: C33H43N3O5
• Molecular Weight: 561.722
• Mol File: 185526-08-3.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[[1-[(2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]- 4-phenylbutyl]amino]-1,1-dimethyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[[1-[(2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]- 4-phenylbutyl]amino]-1,1-dimethyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R)-(185526-08-3)
• EPA Substance Registry System: Carbamic acid, [2-[[1-[(2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]- 4-phenylbutyl]amino]-1,1-dimethyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R)-(185526-08-3)

Safety Data

• Hazardous Substances Data: 185526-08-3(Hazardous Substances Data)

Upstream product

• 30992-29-1 Boc-Aib-OH 
• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 
• 180465-55-8 spiro[1H-indene-1,4'-piperidin]-3(2H)-one 
• 159634-59-0 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 

Relevant articles and documents

The synthesis and activity of spiroindane growth hormone secretagogues

The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.