185526-08-3Relevant academic research and scientific papers
The synthesis and activity of spiroindane growth hormone secretagogues
Tata, James R.,Nargund, Ravi P.,Murphy, Marcia M.,Johnston, David B. R.,Patchett, Arthur A.,Cheng, Kang,Wei, Liente,Chan, Wanda W.-S.,Butler, Bridget,Jacks, Thomas M.,Hickey, Gerard,Smith, Roy
, p. 663 - 668 (2007/10/03)
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.
