18554-51-3

Upstream product

• 5501-37-1 1-methylfluoren-9-one 
• 100-59-4 phenylmagnesium chloride 
• 615-37-2 ortho-methylphenyl iodide 
• 59142-47-1 (2-bromophenyl)phenylmethanol 
• 36804-44-1 N-(2-(2-methylbenzoyl)phenyl)acetamide 

Downstream Products

• 18554-50-2 1-methyl-9-phenyl-9H-fluorene 

Relevant academic research and scientific papers

Synthesis of fluorenyl alcohols: Via cooperative palladium/norbornene catalysis

Herein, we report a novel catalytic synthesis of substituted 9H-fluoren-9-ols starting from aryl iodides and secondary ortho-bromobenzyl alcohols in the presence of palladium/norbornene as a catalytic system. The present protocol exhibits high functional

A sequential Pd/norbornene-catalyzed process generates o- biaryl carbaldehydes or ketones via a redox reaction or 6 h -dibenzopyrans by C-O ring closure

o-Biaryl carbaldeydes and ketones are obtained through the one-pot reaction of o-aryl iodides with o-bromobenzyl alcohols under the catalytic action of Pd and norbornene, in the presence of a base. The same reaction can also give dibenzopyrans by Pd and norbornene catalysis with a different termination, leading to C-O ring closure. In both cases the process first leads to a five-membered palladacycle, which controls C-C coupling, then to a seven-membered oxapalladacycle, which gives aldehydes and ketones or dibenzopyrans.

Tricylic amino-acid derivatives

Described herein are compounds which have the general formula: or a prodrug or pharmaceutically acceptable salt, solvate or hydrate thereof wherein: R1 is selected from the group consisting of H, alkyl and the counter ion for a basic addition salt; X is selected from the group consisting of CR9R10, S, O, SO, SO2, NH and N-alkyl; R2, R3, R4, R9 and R10 are independently selected from the group consisting of H and alkyl; R5 and R6 are independently selected from the group consisting of H, alkyl and phenyl, or, alternatively, R5 and R6 together may form a methylene group or a 3- to 6-membered a spirocyclic group; wherein, when X is CR9R10, one or both pairs of R5 and R9 or R6 and R10 may join to form a double or triple bond R7 is selected from the group consisting of Formula II-V: which are all optionally substituted, at nodes other than R8, with 1-4 substituents independently selected from the group consisting of alkyl, halo, aryl (which may be substituted as for R8), trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; and wherein any of the benzo-fused rings in structures II to V may be replaced by a 5- or 6-membered heterocyclic ring selected from the group consisting of pyridine, thiophene, furan and pyrrole; wherein R8 is selected from the group consisting of H, alkyl, benzyl, cycloalkyl, indanyl and an optionally substituted aryl group, wherein the optional substituents are independently selected from 1-4 members of the group consisting of alkyl, halo, aryl, trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; -represents a single or double bond; Y is selected from the group consisting of O, S, SO, NH, N-alkyl, CH2, CH-alkyl, C(alkyl)2, and C=O; Z is selected from the group consisting of CH2, O, S, NH and N-alkyl when-is a single bond; Z is selected from the group consisting of CH and N when-is a double bond. Also described is the use of these compounds as pharmaceuticals.