185685-59-0Relevant academic research and scientific papers
Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses
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, (2008/06/13)
The invention relates to novel biaromatic compounds having general formula I and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovascular, and ophthalmological disorders, and for use in cosmetic compositions.
Application of the Heck reaction in the synthesis of truncated naphthoic acid retinoids
Yu, Kuo-Long,Chen, Simon,Ostrowski, Jacek,Tramposch, Kenneth M.,Reczek, Peter R.,Mansuri, Muzammil M.,Starrett Jr., John E.
, p. 2859 - 2864 (2007/10/03)
A series of truncated naphthoic acid retinoids have been prepared using the Heck reaction. These retinoids were evaluated in the RAR transactivation assay in vitro and in the utriculi reduction assay in vivo. It has been found that the naphthalene ring of the retinoids is crucial for their retinoid activity and receptor selectivity.
