1857-05-2

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dimethoxy-4-phenylcoumarin is used as a potential therapeutic agent for various conditions due to its anti-inflammatory, antioxidant, and anticancer properties. Its pharmacological activities make it a promising candidate for the development of new drugs to treat inflammation, oxidative stress-related diseases, and cancer.
Used in Analytical Chemistry:
6,7-Dimethoxy-4-phenylcoumarin is used as a fluorescent probe for detecting metal ions. Its unique structure allows it to selectively bind to specific metal ions, making it a valuable tool in analytical chemistry for the detection and quantification of metal ions in various samples.
Used in Research and Development:
6,7-Dimethoxy-4-phenylcoumarin is used as a target for further research and development of new pharmaceuticals. Its potential biological activities and unique structure make it an interesting compound for exploring new therapeutic applications and understanding its mechanism of action.

Upstream product

• 482-82-6 nordalbergin 
• 77-78-1 dimethyl sulfate 
• 36896-99-8 2-hydroxy-4,5-dimethoxybenzophenone 
• 108-24-7 acetic anhydride 
• 120-08-1 Scoparone 
• 71-43-2 benzene 
• 2033-89-8 3,4-dimethoxyphenol 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 482-83-7 6-Hydroxy-7-methoxy-4-phenyl-coumarin 
• 74-88-4 methyl iodide 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 110420-59-2 5,6-dimethoxy-3-phenyl-benzofuran-2-carboxylic acid 
• 108837-09-8 5,6-dimethoxy-3-phenylbenzofuran 
• 108982-12-3 3-bromo-6,7-dimethoxy-4-phenyl-coumarin 
• 482-83-7 6-Hydroxy-7-methoxy-4-phenyl-coumarin 
• 109469-67-2 3-phenyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid 

Relevant academic research and scientific papers

Palladium-Acid Co-Catalyzed Cleavage of Alkynoates to Construct Dibenzo[c,h]xanthene Derivatives

A novel palladium-acid co-catalyzed C(sp)?C(sp2) cleavage of alkynoates for the construction of dibenzo[c,h]xanthene derivatives is reported. A catalytic amount of triflic acid (TfOH) afforded an efficient transformation into the final product. Furthermore, a reduction process of alkynoates was observed during the formation of dibenzo[c,h]xanthene, preliminary mechanistic studies indicated that the protonation of the new-formed methyl group in dibenzo[c,h]xanthene mainly came from water. (Figure presented.).

Design and synthesis of dalbergin analogues and evaluation of anti-osteoporotic activity

The chemical modifications of the hydroxyl group of dalbergin have been described via the introduction of cyclic amine, ester and amide groups. Among the twenty-three prepared novel analogues of dalbergin, compound 4d (EC50 2.3?μM) showed significantly increased proliferation as assessed by alkaline phosphatase activity and mineralization in calvarial osteoblast cells in vitro. Compound 4d, at a dose of 1.0?mg/kg body weight exhibited the significant osteoprotective effect. It showed a significant increase in osteogenic gene expression RunX2 (～4fold), ALP (～5fold), OCN (～4fold) and COL1 (～4fold) as compared to control group at the same dose in vivo assay.

Regioselective palladium-catalyzed direct cross-coupling of coumarins with simple arenes

An efficient method for the C4-regiocontrolled C-H functionalization of coumarins to enable facile oxidative cross-couplings with simple arene components is disclosed.

Microwave-promoted, one-pot, solvent-free synthesis of 4-arylcoumarins from 2-hydroxybenzophenones

4-Arylcoumarins are synthesized in very good yields through solvent-free microwave irradiation of 2-hydroxybenzophenones and alkyl malonate in the presence of DBU. The onepot synthesis is carried out with Knoevenagel condensation, intramolecular lactonization, and decarboxylation reactions. The method can be applied to a broad scope of neoflavonoids.

New Phenolic Components from Dalbergia Volubilis

Phytochemical examination of non green branches of Dalbergia volubilis on extensive column and preparative thin layer chromatography yielded twelve compounds eight of which are already known compounds and were identified as sitosterol, 7-hydroxy-4-methyl-coumarin, dalbergin, biochanin-A, umbelliferone, p-hydroxy cinnamic acid, kaempferol and quercetin-3-O-glucoside.The other four compounds were new natural products, three of which were identified as novel 4-phenyl-2H-1-benzopyran-2-ones while the fourth one was a new 12a-hydroxy rotenoid.The structure of these new compounds has been established on the basis of chemical and spectral evidences and through derivatization, as 4',7-dihydroxy-3'-methoxy-4-phenyl-2H-1-benzopyran-2-one, 3',7-dihydroxy-4',5-dimethoxy-2H-1-benzopyran-2-one, 3',7-dihydroxy4',5-dimethoxy-6-formyl-2H-1-benzopyran-2-one and a complex rotenoid determined to be as (VII).The co-occurence of 4-methyl-2H-1-benzopyran-2-ones, 4-phenyl-2H-1-benzopyran-2-ones, isoflavones and rotenoids is of interest from biogenetic considerations.