185896-84-8

Basic information

• Product Name: ethyl 2-(2-( 1,3-dioxolan-2-yl)phenyl)-2-oxoacetate
• Synonyms: ethyl 2-(2-( 1,3-dioxolan-2-yl)phenyl)-2-oxoacetate
• CAS NO: 185896-84-8
• Molecular Weight: 250.251
• Mol File: 185896-84-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-( 1,3-dioxolan-2-yl)phenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-( 1,3-dioxolan-2-yl)phenyl)-2-oxoacetate(185896-84-8)
• EPA Substance Registry System: ethyl 2-(2-( 1,3-dioxolan-2-yl)phenyl)-2-oxoacetate(185896-84-8)

Safety Data

• Hazardous Substances Data: 185896-84-8(Hazardous Substances Data)

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 95-92-1 oxalic acid diethyl ester 
• 164718-49-4 (2-(1,3-dioxolan-2-yl)phenyl)-magnesium bromide 

Downstream Products

• 380917-97-5 [14C]-Perampanel 
• 152303-03-2 Ethyl α-(2-formylphenyl)acrylate 
• 258854-88-5 ethyl 2-{2-(1,3-dioxolan-2-yl)phenyl}-2-methoxyiminoacetate 
• 185896-83-7 (Z)-2-[2-(1,3-dioxolan-2-yl)phenyl]-2-methoxyimino-N-methylacetamide 
• 185896-85-9 (2-[1,3]dioxolan-2-yl-phenyl)-methoxyimino-acetic acid ethyl ester 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL

The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2- pyridyl)-1-phenyl-1,2-dihydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.

Practical Asymmetric Synthesis of (S)-MA20565, a Wide-Spectrum Agricultural Fungicide

A practical asymmetric synthesis of a wide-spectrum agricultural fungicide, (S)-MA20565 (1), is described. The convergent synthesis was achieved starting from commercially available 3-(trifluoromethyl)aniline (7) in 44% overall yield through five steps and 2-bromobenzaldehyde (9) in 48% overall yield through four steps, respectively. (S)-O-[1-(3-Trifluoromethylphenyl)ethyl]hydroxylamine (2), a key intermediate of 1, was prepared via ruthenium(II)-catalyzed asymmetric transfer hydrogenation of 1-(3-trifluoromethylphenyl)ethanone (6) followed by chlorination using methanesulfonyl chloride and oxyamination using potassium acetohydroxamate with high level of stereocontrol.

PROCESS FOR PRODUCING N-METHYL-METHOXYIMINOACETAMIDE DERIVATIVES AND INTERMEDIATES THEREOF

A method for producing an N-methyl-methoxyiminoacetamide derivative represented by the following general formula (I) (wherein R3represents a hydrogen atom or a group represented by a general formula -C(R4)(R5)-Ar (wherein