185913-28-4Relevant articles and documents
Method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid
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Paragraph 0008; 0018-0019; 0021, (2020/06/17)
The invention belongs to the field of synthesis of pharmaceutical compounds, and provides a method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid. The method comprises the following two steps:1) synthesizing an intermediate: reacting 3-fluorophenol
General Synthetic Approach to Rotenoids via Stereospecific, Group-Selective 1,2-Rearrangement and Dual S N Ar Cyclizations of Aryl Fluorides
Matsuoka, Seiya,Nakamura, Kayo,Ohmori, Ken,Suzuki, Keisuke
, p. 1139 - 1156 (2019/02/26)
A general synthetic approach to rotenoids is described, featuring 1) stereospecific, group-selective 1,2-rearrangements of epoxy alcohols, and 2) S N Ar oxy-cyclizations of aryl fluorides. The common intermediate epoxyketone, en route to (-)-rotenone and (-)-deguelin, was prepared from d -araboascorbic acid in five steps. Also described is the conversion of (-)-deguelin into oxidized congeners, (-)-tephrosin and (+)-12a- epi -tephrosin.
Foiling Normal Patterns of Crystallization by Design. Polymorphism of Phosphangulene Chalcogenides
Heskia, Alice,Maris, Thierry,Wuest, James D.
, p. 5390 - 5406 (2019/09/12)
Phosphangulene (1) has a well-defined hexacyclic structure with a distinctive conical shape and an electron-rich aromatic surface. Molecules of phosphangulene are disposed to crystallize in parallel π-stacks. This preference can be thwarted by adding a si
Boron compound conjugated π, electronic device, and triazoles [...] number bath preparation method
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Paragraph 0226; 0229; 0231, (2019/01/06)
There are provided a π-conjugated boron compound, an electronic device containing an organic functional layer including the π-conjugated boron compound, a method for producing a triarylborane, and a method for producing a triarylborane intermediate. In the π-conjugated boron compound, a boron atom is bonded to three aromatic groups via three boron-carbon bonds. Bond distances of the three boron-carbon bonds are all 1.48 ? or less.
C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF
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Paragraph 0096; 0378; 0379; 0380, (2017/04/19)
This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.
Synthesis, structure, and properties of 4,8,12-trioxa-12c-phospha-4,8,12,12c-tetrahydrodibenzo[cd,mn]pyrene, a molecular pyroelectric
Krebs, Frederik C.,Larsen, Peter S.,Larsen, Jan,Jacobsen, Claus S.,Boutton, Carlo,Thorup, Niels
, p. 1208 - 1216 (2007/10/03)
The title compound (4) was synthesized, and its crystalline structure was determined. The molecule has C(3v) point symmetry and crystallizes in the trigonal space group R3m. Crystal data for 4: a = 16.6710(13) ?, b = 16.6710(13) ?, c = 4.2590(3) ?, α = β
Regioselective synthesis of 6-substituted 2-hydroxybenzaldehyde: Efficient synthesis of the immunomodulator tucaresol and related analogues
Zacharie, Boulos,Attardo, Giorgio,Barriault, Nancy,Penney, Christopher
, p. 2925 - 2929 (2007/10/03)
Two new improved procedures have been developed for the preparation of the immunostimulant tucaresol 1 [4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid]. These approaches, which start from resorcinol or 2,6-dimethoxybenzaldehyde, are practical and therefore amenable to scale-up. In the case of the second approach, the multi-step synthesis reported in the literature has been reduced to three steps. Furthermore, unlike the reported method, our synthesis is versatile for the preparation of tucaresol analogues. The method is general and applicable for the preparation of 6-substituted 2-hydroxybenzaldehydes.
