199388-02-8

Basic information

• Product Name: 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde
• Synonyms: 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde
• CAS NO: 199388-02-8
• Molecular Weight: 224.232
• Mol File: 199388-02-8.mol

Chemical Properties

• CAS DataBase Reference: 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde(199388-02-8)
• EPA Substance Registry System: 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde(199388-02-8)

Safety Data

• Hazardous Substances Data: 199388-02-8(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 372-20-3 3-fluorophenol 
• 68-12-2 N,N-dimethyl-formamide 
• 185913-28-4 2-(3-fluorophenoxy)tetrahydro-2H-pyran 

Downstream Products

• 199388-06-2 4-(3-Fluoro-2-formyl-phenoxymethyl)-benzoic acid methyl ester 
• 38226-10-7 2-fluoro-6-hydroxybenzaldehyde 

Relevant articles and documents

Regioselective synthesis of 6-substituted 2-hydroxybenzaldehyde: Efficient synthesis of the immunomodulator tucaresol and related analogues

Two new improved procedures have been developed for the preparation of the immunostimulant tucaresol 1 [4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid]. These approaches, which start from resorcinol or 2,6-dimethoxybenzaldehyde, are practical and therefore amenable to scale-up. In the case of the second approach, the multi-step synthesis reported in the literature has been reduced to three steps. Furthermore, unlike the reported method, our synthesis is versatile for the preparation of tucaresol analogues. The method is general and applicable for the preparation of 6-substituted 2-hydroxybenzaldehydes.

C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF

This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.