18597-93-8

Basic information

• Product Name: Hydrazinecarboxylic acid, 1-methyl-1-phenylethyl ester (9CI)
• Synonyms: Hydrazinecarboxylic acid, 1-methyl-1-phenylethyl ester (9CI)
• CAS NO: 18597-93-8
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• Product Categories: N-BOC
• Mol File: 18597-93-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Hydrazinecarboxylic acid, 1-methyl-1-phenylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 1-methyl-1-phenylethyl ester (9CI)(18597-93-8)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 1-methyl-1-phenylethyl ester (9CI)(18597-93-8)

Safety Data

• Hazardous Substances Data: 18597-93-8(Hazardous Substances Data)

Upstream product

• 53933-09-8 2-phenylisopropyloxycarbonyl phenyl carbonate 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 93-58-3 benzoic acid methyl ester 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 49855-55-2 7t-[N'-(1-methyl-1-phenyl-ethoxycarbonyl)-hydrazinocarbonyl]-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid tert-butyl ester 
• 49855-55-2 7c-[N'-(1-methyl-1-phenyl-ethoxycarbonyl)-hydrazinocarbonyl]-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid tert-butyl ester 
• 37469-77-5 7c-methyl-7t-[N'-(1-methyl-1-phenyl-ethoxycarbonyl)-hydrazinocarbonyl]-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid tert-butyl ester 

Relevant articles and documents

Urotensin II(4-11) Azasulfuryl Peptides: Synthesis and Biological Activity

Cyclic azasulfuryl (As) peptide analogs of the urotensin II (UII, 1, H-Glu-Thr-Pro-Asp-c[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) fragment 4-11 were synthesized to explore the influences of backbone structure on biological activity. N-Aminosulfamides were inserted as surrogates of the Trp7 and Lys8 residues in the biologically relevant Trp-Lys-Tyr triad. A combination of solution- and solid-phase methods were used to prepare novel UII(4-11) analogs 6-11 by routes featuring alkylation of azasulfuryl-glycine tripeptide precursors to install various side chains. The pharmacological profiles of derivatives 6-11 were tested in vitro using a competitive binding assay and ex vivo using a rat aortic ring bioassay. Although the analogs exhibited weak affinity for the urotensin II receptor (UT) without agonistic activity, azasulfuryl-UII(4-11) derivatives 7-9 reduced up to 50% of the effects of UII and urotensin II-related peptide (URP) without affecting their potency.

Peptide synthesis under application of the 2-(p-diphenyl)-isopropyloxycarbonyn (Dpoc)-amino protection groups

-