18598-31-7

Upstream product

• 61-33-6 penicillin G 
• 1254-56-4 benzyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 113-98-4 Penicillin G potassium 
• 101522-53-6 1,1-dioxo-6β-(2-phenyl-acetylamino)-1λ⁶-penicillanic acid benzyl ester 
• 99673-34-4 1,1-dioxo-6β-(2-phenyl-acetylamino)-1λ⁶-penicillanic acid cyanomethyl ester 

Downstream Products

• 121002-98-0 methoxymethyl benzylpenicillinate 1,1-dioxide 
• 71840-43-2 methyl 2-(2,4-dioxo-3-phenylacatamidoazetidin-1-yl)-3-methylbut-2-enoate 
• 121003-03-0 2-(2,4-dioxo-3-phenylacatamidoazetidin-1-yl)-3-methylbut-2-enoic acid 
• 121003-02-9 methoxymethyl 2-(2,4-dioxo-3-phenylacatamidoazetidin-1-yl)-3-methylbut-2-enoate 
• 121003-00-7 methoxymethyl 2-<(1R,5S)-3-benzyl-7-oxo-4-oxa-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>-3-methylbut-2-enoate 
• 121002-99-1 (2R,3S)-1-(1-methoxymethoxycarbonyl-2-methylprop-1-enyl)-4-oxo-3-phenylacetamidoazetidine-2-sulphinic acid 
• 121003-01-8 methoxymethyl 3-methyl-2-<(3R,4R)-2-oxo-3-phenylacetamido-4-pyruvoyloxyazetidin-1-yl>but-2-enoate 

Relevant academic research and scientific papers

SOME APPROACHES TO THE SYNTHESIS OF SULBACTAM

A study on the synthesis of penicillanic acid 1,1-dioxide, Sulbactam, was carried out.Two reliable convergent synthetic routes to this β-lactamase inhibitor starting from penicillin G potassium salt and 6-aminopenicillanic acid have been developed.

Process for preparing cephem lactones for cephalosporin-type antibiotics

Cephem lactones of formula (1) STR1 wherein R1 is hydrogen or an organic substituent of the type appearing as the 6-substituent of penicillins or as the 7-substituent of cephalosporins are produced from corresponding 4,5-halohydrin precursors thereof by dehalogenation. Novel stereoisomers of formula (1) compounds as well as novel intermediates for cephem lactone syntheses are disclosed. The cephem lactones produced according to the invention are of utility as intermediates for cephem-type antibiotics and have antibiotic properties of their own.