18598-95-3

Upstream product

• 16537-09-0 t-butyl phenylacetate 
• 35132-16-2 tert-butyl α-bromo-α-phenylacetate 
• 108-86-1 bromobenzene 
• 18598-93-1 α-nitro tert-butyl acetate 

Downstream Products

• 1252671-74-1 tert-butyl 2-nitro-2-phenylbut-3-ynoate 
• 1380548-84-4 C₁₇H₂₁NO₄ 
• 1380419-34-0 (E)-tert-butyl 2-nitro-2-phenylhepta-4,6-dienoate 

Relevant academic research and scientific papers

Efficient palladium-catalyzed cross-coupling of highly acidic substrates, nitroacetates

Palladium-catalyzed cross-coupling conditions were developed that efficiently afford 2-aryl-2-nitroacetates from aryl bromides and the very acidic nitroacetates.

Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An exceptional reagent for the ethynylation of keto, cyano, and nitro esters

Hot alkyne! The in situ generation of ethynyl-1,2-benziodoxol-3(1H)-one (EBX) from a silyl-protected reagent by using TBAF is reported. EBX displayed exceptional acetylene transfer ability onto stabilized enolates (see scheme), even at -78 □°C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano, and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.