1860-46-4Relevant articles and documents
2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives
Shirai, Takahiro,Kanai, Motomu,Kuninobu, Yoichiro
supporting information, p. 1593 - 1596 (2018/03/23)
We developed 2-position-selective, direct C-H trifluoromethylation, pentafluoroethylation, and heptafluoropropylation of quinoline derivatives. Regioselective transformation was achieved without derivatization of the quinolines. The reaction proceeded at room temperature with high functional group tolerance, even in gram scale. Notably, the reaction was applicable to substrates containing a functional group sensitive to oxidation and a drug molecule.
New regiospecific synthesis of 2-trifluoromethyl-1,5 diazapentadiene compounds and of 2-trifluoromethylquinolines, their cyclization products
El Kharrat, Salem,Skander, Myriem,Dahmani, Abdelkader,Laurent, Philippe,Blancou, Hubert
, p. 8327 - 8331 (2007/10/03)
2-Trifluoromethylquinolines 5 are synthesized in high yields using a perfluoroalkylated gemiodoacetoxy derivative 3 and arylamines 4. The intermediate of this reaction, 2-trifluoromethyl-1,5-diazapentadiene compound 6, was isolated. The procedures are eas
2-(trifluoromethyl)quinolines from anilines: A novel mode of isomerization and cyclization
Keller,Schlosser
, p. 4637 - 4644 (2007/10/03)
Deprotonation of N-ethylidene-tert-butylamine with lithium diisopropylamide and subsequent condensation with ethyl trifluoroacetate gives 4-tert-butylamino-1,1,1-trifluorobut-3-en-2-one. An exchange of the amino substituent occurs when the latter compound
