18600-57-2

Usage

Chemical structure

2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one is a chemical compound with a benzoxazinone backbone.

Antioxidant properties

The compound is known for its ability to scavenge free radicals, which can damage cells and contribute to various diseases and conditions.

Anti-inflammatory properties

2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one has been shown to reduce inflammation, which is a key factor in many diseases and conditions.

Therapeutic potential

The compound has been studied for its potential use in treating various diseases and conditions, including cancer, arthritis, and cardiovascular diseases.

Pharmaceutical industry interest

Due to its antioxidant and anti-inflammatory properties, 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one is an interesting target for further research and development in the pharmaceutical industry.

Upstream product

• 102-92-1 cinnamoyl chloride 
• 118-92-3 anthranilic acid 
• 22780-31-0 N-cinnamoylanthranilic acid 

Downstream Products

• 68142-77-8 3-(5-methyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 68142-79-0 3-(5-propyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 68142-80-3 3-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 76983-24-9 C₂₃H₁₈N₄O₄S 
• 76983-32-9 C₂₄H₂₀N₄O₄S 
• 76983-39-6 C₂₄H₂₀N₄O₅S 
• 76983-47-6 C₂₅H₂₁N₅O₅S 
• 37856-33-0 4-(4-oxo-2-styryl-4H-quinazolin-3-yl)-benzoic acid 
• 74796-85-3 3-(5-bromomethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 74796-90-0 3-[5-(diethylamino-methyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 
• 74796-92-2 3-(5-anilinomethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 74796-94-4 3-(5-morpholin-4-ylmethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 74796-93-3 3-[5-(2-methyl-anilinomethyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 
• 74796-91-1 3-[5-(diphenylamino-methyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 

Relevant academic research and scientific papers

A quinazolinone and pyrazole compound and its synthesis method

The invention relates to a quinazolinone and pyrazole compound and a synthesis method for the same. The quinazolinone and pyrazole compound is shown as a formula (I). The synthesis method includes steps of S1, carrying out reaction on compounds shown as a

A quinazolinone and pyrazoline compound and its preparation method

The invention relates to a quinazolinonedihydropyrazol compound as shown in formula (I) and a preparation method thereof. The preparation method comprises the following steps: in an organic solvent, reacting a compound as shown in formula (II) with a comp

Catalytic aza-wittig reaction of acid anhydride for the synthesis of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones

Compared to the aza-Wittig reaction of aldehydes, ketones, amides, and esters, the aza-Wittig reaction of acid anhydride was always overlooked, which should be an important part of Wittig reactions. Here, the aza-Wittig reaction of anhydride and catalytic aza-Wittig reaction of anhydride were both developed with high yields, which provides an efficient method to synthesize of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones. The strategy of copper-catalyzed reduction of phosphine oxide was used and found effective for this transformation. Additionally, the one-pot catalytic aza-Wittig reaction of carboxylic acids was achieved. Furthermore, NMR experiments and Hammett plot recorded the process of catalytic aza-Wittig reaction of anhydride, which provides direct proof that the copper-catalyzed reduction of waste phosphine oxide is the key step in this transformation.

Synthesis and antiviral activities of some 2,3-disubstituted quinazoline derivatives

In the search of new leads towards potent antiviral agents 2,3-disubstituted quinazoline derivatives were synthesized and tested for their antiviral activity. Anthranilic acid (1) on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines (2) which in turn reacts with p-amino benzoic acid (PABA) to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines (3). The compound 3 further reacts with amido alcohols in the presence of conc. H2SO4 resulting 3-[benzoic acid-(3-phthalimidomethyl/3-ethyl-3H-2-phenyl- 4-oxo-quinazolinyl/1-ethyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)]-2-aryl-3H-quinazoline-4-ones (4). The resulting compounds 4a-f have been evaluated for their in vitro and in vivo antiviral activity against JEV and HSV type-I. The synthesized compounds were characterized through their physical and chemical analysis. The obtained results can be used as the key step for the building of novel chemical entities with interesting antiviral activity compare with the standard drugs.

Silica-bound benzoyl chloride mediated the solid-phase synthesis of 4H-3, 1-benzoxazin-4-ones

The solid-phase synthesis of 4H-3, 1-benzoxazin-4-ones was achieved using silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with 2-acylaminobenzoic acids. The silica-grafted reagent (SBBC) was simply recovered after reaction and reused several times.

Synthesis and biological properties of 4-(3H)-quinazolone derivatives

A new quinazolone series has been designed, and synthesized by the anthranilic acid and different acid derivatives. Their structures have been elucidated on the basis of elemental analyses and spectral studies (IR, 1H NMR, FT-IR and FAB-MS). A

Synthesis, characterization and antiviral activity of 2,3-disubstituted quinazolones

Anthranilic acid on reaction with excess equivalent of an aromatic acid chloride in pyridine yields 2-aryl-4-oxo-3,1-benzoxazines (1). Reaction of 1 with p-aminophenol in pyridine furnishes 2-aryl-3-(4-hydroxyphenyl)-4-oxo(3if)- quinazolones (2) which rea

A new synthesis of 2-substituted 4H-3,1-benzoxazin-4-ones by cyanuric chloride cyclodehydration of N-benzoyl- and N-acylanthranilic acids

A new and a convenient method for the synthesis of aryl- and alkyl-2-substituted 4H-3,1-benzoxazin-4-ones by cyclodehydration of N-benzoyl- and N-acylanthranilic acid by cyanuric chloride is described.