18600-57-2

Basic information

• Product Name: 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one
• CAS NO: 18600-57-2
• Molecular Formula: C₁₆H₁₁NO₂
• Molecular Weight: 249.264
• Mol File: 18600-57-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 417.8°C at 760 mmHg
• Flash Point: 197°C
• Density: 1.16g/cm³
• Vapor Pressure: 3.43E-07mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one(18600-57-2)
• EPA Substance Registry System: 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one(18600-57-2)

Safety Data

• Hazardous Substances Data: 18600-57-2(Hazardous Substances Data)

Usage

Chemical structure

2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one is a chemical compound with a benzoxazinone backbone.

Antioxidant properties

The compound is known for its ability to scavenge free radicals, which can damage cells and contribute to various diseases and conditions.

Anti-inflammatory properties

2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one has been shown to reduce inflammation, which is a key factor in many diseases and conditions.

Therapeutic potential

The compound has been studied for its potential use in treating various diseases and conditions, including cancer, arthritis, and cardiovascular diseases.

Pharmaceutical industry interest

Due to its antioxidant and anti-inflammatory properties, 2-(2-phenylethenyl)-4H-3,1-benzoxazin-4-one is an interesting target for further research and development in the pharmaceutical industry.

Upstream product

• 118-92-3 anthranilic acid 
• 102-92-1 cinnamoyl chloride 
• 22780-31-0 N-cinnamoylanthranilic acid 

Downstream Products

• 68142-78-9 3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 68501-37-1 3-(2-hydroxyethyl)-2-(2-phenylethenyl)quinazolin-4(3H)-one 
• 112750-80-8 2-styryl-3-(4-hydroxyphenyl)-4-oxo(3H)-quinazoline 
• 74796-91-1 3-[5-(diphenylamino-methyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 
• 74796-93-3 3-[5-(2-methyl-anilinomethyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 
• 74796-94-4 3-(5-morpholin-4-ylmethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 74796-92-2 3-(5-anilinomethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 74796-90-0 3-[5-(diethylamino-methyl)-[1,3,4]thiadiazol-2-yl]-2-styryl-3H-quinazolin-4-one 
• 74796-85-3 3-(5-bromomethyl-[1,3,4]thiadiazol-2-yl)-2-styryl-3H-quinazolin-4-one 
• 37649-32-4 3-amino-2-styrylquinazolin-4(3H)-one 
• 37856-33-0 4-(4-oxo-2-styryl-4H-quinazolin-3-yl)-benzoic acid 
• 76983-47-6 C₂₅H₂₁N₅O₅S 
• 76983-39-6 C₂₄H₂₀N₄O₅S 
• 76983-32-9 C₂₄H₂₀N₄O₄S 

Relevant articles and documents

A quinazolinone and pyrazole compound and its synthesis method

The invention relates to a quinazolinone and pyrazole compound and a synthesis method for the same. The quinazolinone and pyrazole compound is shown as a formula (I). The synthesis method includes steps of S1, carrying out reaction on compounds shown as a

Catalytic aza-wittig reaction of acid anhydride for the synthesis of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones

Compared to the aza-Wittig reaction of aldehydes, ketones, amides, and esters, the aza-Wittig reaction of acid anhydride was always overlooked, which should be an important part of Wittig reactions. Here, the aza-Wittig reaction of anhydride and catalytic aza-Wittig reaction of anhydride were both developed with high yields, which provides an efficient method to synthesize of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones. The strategy of copper-catalyzed reduction of phosphine oxide was used and found effective for this transformation. Additionally, the one-pot catalytic aza-Wittig reaction of carboxylic acids was achieved. Furthermore, NMR experiments and Hammett plot recorded the process of catalytic aza-Wittig reaction of anhydride, which provides direct proof that the copper-catalyzed reduction of waste phosphine oxide is the key step in this transformation.

Silica-bound benzoyl chloride mediated the solid-phase synthesis of 4H-3, 1-benzoxazin-4-ones

The solid-phase synthesis of 4H-3, 1-benzoxazin-4-ones was achieved using silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with 2-acylaminobenzoic acids. The silica-grafted reagent (SBBC) was simply recovered after reaction and reused several times.