37856-33-0Relevant academic research and scientific papers
Synthesis and antiviral activities of some 2,3-disubstituted quinazoline derivatives
Gupta,Singh, Joginder,Kinger, Mayank,Arora, Avnish Kumar,Jaswal, Vivek Sheel
, p. 4379 - 4382 (2015/11/28)
In the search of new leads towards potent antiviral agents 2,3-disubstituted quinazoline derivatives were synthesized and tested for their antiviral activity. Anthranilic acid (1) on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines (2) which in turn reacts with p-amino benzoic acid (PABA) to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines (3). The compound 3 further reacts with amido alcohols in the presence of conc. H2SO4 resulting 3-[benzoic acid-(3-phthalimidomethyl/3-ethyl-3H-2-phenyl- 4-oxo-quinazolinyl/1-ethyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)]-2-aryl-3H-quinazoline-4-ones (4). The resulting compounds 4a-f have been evaluated for their in vitro and in vivo antiviral activity against JEV and HSV type-I. The synthesized compounds were characterized through their physical and chemical analysis. The obtained results can be used as the key step for the building of novel chemical entities with interesting antiviral activity compare with the standard drugs.
Synthesis and characterisation of isoquinolinyl quinazolines and a study of their antiviral and antifungal activities
Pandey,Pathak,Mishra
, p. 1940 - 1943 (2007/10/03)
Anthranilic acid on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines 1 which reacts with p-aminobenzoic acid to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines 2. Interaction of 2 with benzoin in the presen
Condensation of 2-Methyl-3,1-benzoxazin-4-one with Schiff Bases: Simultaneous Introduction of Arylidene and Amine Moieties
Kumar, Pradeep,Mukerjee, Arya K.
, p. 24 - 26 (2007/10/02)
2-Methyl-3,1-benzoxazin-4-one (3), generated by cyclising N-acetylanthranilic acid with ethyl chloroformate in benzene containing triethylamine, reacts with schiff bases in situ when heated under reflux in gl. acetic acid to give 3-substituted 2-styryl-3,4-dihydro-4-quinazolones (7).
