186028-79-5

Basic information

• Product Name: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
• Synonyms: Methylenedioxymethcathinone hydrochloride;2-MethylaMino-1-(3;4-Methylenedioxyphenyl)propan-1-one;2-MethylaMino-1-(3,4-Methylenedioxyphenyl)propan-1;2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one;2-Methylamino-(3,4-Methylenedioxyphenyl)Propan-1-OneHydro;2-Methylamio-1-(3,4-Methylenedioxyphenyl)Propan-1-OneHcl(Methylone);2-METHYLAMINO-1-(3,4-METHYLENEDIOXIPHENYL)PROPAN-1-ONE
• CAS NO: 186028-79-5
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• Product Categories: Research Chemical;Chemical for Research;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 186028-79-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 350.1 °C at 760 mmHg
• Flash Point: 165.5 °C
• Appearance: /
• Density: 1.188 g/cm³
• Vapor Pressure: 4.5E-05mmHg at 25°C
• Refractive Index: 1.546
• PKA: 7.74±0.10(Predicted)
• CAS DataBase Reference: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(186028-79-5)
• EPA Substance Registry System: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(186028-79-5)

Safety Data

• Hazardous Substances Data: 186028-79-5(Hazardous Substances Data)

Usage

Uses

It is a ?ketone analogue of MDMA (Ecstasy). It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA

InChI:InChI=1/C11H13NO3/c1-7(12-2)11(13)8-3-4-9-10(5-8)15-6-14-9/h3-5,7,12H,6H2,1-2H3

Upstream product

• 186028-79-5 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one 
• 274-09-9 Methylenedioxybenzene 
• 28281-49-4 3,4-methylenedioxypropiophenone 
• 52190-28-0 1-(3,4-(methylenedioxy)phenyl)-2-bromopropan-1-one 
• 74-89-5 methylamine 

Downstream Products

• 186028-79-5 S-(+)-methylone 
• 186028-79-5 R-(+)-methylone 
• 80535-73-5 3,4-Methylenedioxycathinone 
• 22930-83-2 3,4-dihydroxymethcathinone 

Relevant articles and documents

Successful use of a novel lux i-Amylose-1 chiral column for enantioseparation of “legal highs” by HPLC

Bath salts, fumigations, cleaners and air fresheners, behind these terms substances are hidden, which count as “Legal Highs”. These fancy names are used to pretend Legal Highs as harmless compounds, to circumvent legal regulations for marketing as well as to increase the sales. Besides classic illicit drugs of synthetic origin such as amphetamines, cocaine and MDMA, the trade of these compounds, also known as new psychoactive substances (NPS), is not uncommon today. In many countries, NPS are still not subject to drug control. Among them, there are stimulants such as new amphetamine derivatives or cathinones, which possess a chiral centre. Little is known about the fact that the two possible enantiomers may differ in their pharmacological effect. The aim of this study was to test a novel HPLC column for the enantioseparation of a set of 112 NPS coming from different chemical groups and collected by internet purchases during the years 2010–2018. The CSP, namely Lux 5?μm i-Amylose-1, LC Column 250 x 4.6?mm, was run in normal phase mode under isocratic conditions, UV detection was performed at 245?nm and 230?nm, injection volume was 10?μl and flow rate was 1?ml/min. With a mobile phase consisting of n-hexane/isopropanol/diethylamine (90:10:0.1), herein, 79 NPS were resolved into their enantiomers successfully, for 37 of them baseline resolution was achieved. After increase of lipophily of the mobile phase to 99:1:0.1, another 27 compounds were baseline separated. It was found that all separated NPS are traded as racemic compounds.

X-ray structures and computational studies of several cathinones

2-(Ethylamino)-1-(4-methylphenyl)propan-1-one (shortly named 4-MEC) (1a), 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one (shortly named methylone or 3,4-methylenedioxymethcathinone) (1b), 1-(3,4-dimethylphenyl)-2-(methylamino) propan-1-one (1c), 2-m