186040-82-4

Upstream product

• 153181-28-3 (4R,5S,6S,7R)-4,7-Dibenzyl-1-cyclopropylmethyl-5,6-bis-(2-methoxy-ethoxymethoxy)-[1,3]diazepan-2-one 
• 153181-25-0 (4R,5S,6S,7R)-hexahydro-5,6-bis(2-methoxyethoxymethoxy)-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one 
• 186040-81-3 3-[(4R,5S,6S,7R)-4,7-Dibenzyl-3-cyclopropylmethyl-5,6-bis-(2-methoxy-ethoxymethoxy)-2-oxo-[1,3]diazepan-1-ylmethyl]-benzonitrile 

Downstream Products

• 1054620-91-5 3-[(4R,5S,6S,7R)-4,7-Dibenzyl-3-cyclopropylmethyl-5,6-bis-(2-methoxy-ethoxymethoxy)-2-oxo-[1,3]diazepan-1-ylmethyl]-N-(1H-imidazol-2-yl)-benzamide 

Relevant academic research and scientific papers

Cyclic urea amides: Hiv-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV

Cyclic urea amides, a novel series of HIV-1 protease (HIV PR) inhibitors, have increased activity against drug-resistant mutants of the HIV PR. The design strategy for these inhibitors is based on the hypotheses that (i) the hydrogen-bonding interactions