186040-81-3Relevant academic research and scientific papers
Cyclic urea amides: Hiv-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV
Jadhav, Prabhakar K.,Ala, Paul,Woerner, Francis J.,Chang, Chong-Hwan,Garber, Sena S.,Anton, Elizabeth D.,Bacheler, Lee T.
, p. 181 - 191 (2007/10/03)
Cyclic urea amides, a novel series of HIV-1 protease (HIV PR) inhibitors, have increased activity against drug-resistant mutants of the HIV PR. The design strategy for these inhibitors is based on the hypotheses that (i) the hydrogen-bonding interactions
