186086-49-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 186086-45-3 3',5'-bis-(O-tert-butyldimethylsilyl)-5-(1,2-diacetoxyethyl)-2'-deoxyuridine 
• 186086-42-0 3',5'-bis-(O-tert-butyldimethylsilyl)-5-(1,2-dihydroxyethyl)-2'-deoxyuridine 
• 186086-47-5 Acetic acid 2-acetoxy-1-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl ester 
• 148134-86-5 2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine 
• 148134-87-6 3',5'-bis-(O-tert-butyldimethylsilyl)-5-vinyl-2'-deoxyuridine 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 186086-48-6 5'-O-(4,4'-dimethoxytrityl)-5-(1,2-diacetoxyethyl)-2'-deoxyuridine 

Relevant academic research and scientific papers

New synthetic method of 5-formyluracil-containing oligonucleotides and their melting behavior

A new method for the synthesis of 5-foU-containing oligonucleotides by phosphoramidite chemistry and subsequent post-oxidation with sodium periodate was developed. 5-(1,2-Dihydroxyethyl)uracil-containing oligomers, which are readily converted to 5-foU-con

Schiff base formation between 5-formyl-2′-deoxy-uridine and lysine e{open}-amino group at monomer and oligomer levels

Schiff base formation between the 5-formyl group of 5-formyl-2′-deoxyuridine, which is an oxidative thymidine lesion, and the e{open}-amino group of lysine at both monomer and oligomer levels is reported.

Introduction of 5-formyl-2'-deoxyuridine into a κB site: Critical discrimination of a base structure in the major groove by NFκB p50 homodimer

Four kinds of oligonucleotide 26-mers including 5-formyl-2'- deoxyuridine in place of thymidine at the κB site were synthesized. One of the oligonucleotide 26-mers was critically discriminated by the NFκB p50 homodimer in binding.