186191-19-5Relevant articles and documents
Rate accelerations of 1,3-dipolar cycloaddition reactions in ionic liquids
Fraga Dubreuil,Bazureau
, p. 7351 - 7355 (2000)
The 1,3-dipolar cycloaddition reactions between imidate 1 derived from diethyl aminomalonate and 2-ethoxybenzaldehyde 2 as dipolarophile has been investigated in various air and moisture stable ionic liquids. Significant rate enhancements and improved yie
Inclusion of C60 into an adjustable porphyrin dimer generated by dynamic disulfide chemistry
Kieran, Amy L.,Pascu, Sofia I.,Jarrosson, Thibaut,Sanders, Jeremy K. M.
, p. 1276 - 1278 (2005)
A new, highly flexible porphyrin dimer was isolated in preparative scale from a dynamic disulfide library; this receptor adjusts to fit guests with a wide range of steric requirements and, whilst C60 proved to be an unsuitable template for this
Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids
Awolade, Paul,Cele, Nosipho,Kerru, Nagaraju,Singh, Parvesh
, p. 2201 - 2218 (2020/06/17)
Abstract: Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to afford multi-target-based drug candidates. Herein, we report a library of quinoline—1H-1,2,3-triazole molecular hybrids synthesized via copper(I)-catalyzed azide-alkyne [3 + 2] dipolar cycloaddition reaction (CuAAC). Antimicrobial evaluation identified compound 16 as the most active hybrid in the library with a broad-spectrum antibacterial activity at an MIC80 value of 75.39?μM against methicillin-resistant S. aureus, E. coli, A. baumannii, and multidrug-resistant K. pneumoniae. The compound also showed interesting antifungal profile against C. albicans and C. neoformans at an MIC80 value of 37.69 and 2.36?μM, respectively, superior to fluconazole. In vitro toxicity profiling revealed non-hemolytic activity against human red blood cells (hRBC) but partial cytotoxicity to human embryonic kidney cells (HEK293). Additionally, in silico studies predicted excellent drug-like properties and the importance of triazole ring in stabilizing the complexation with target proteins. Overall, these results present compound 16 as a promising scaffold on which other molecules can be modeled to deliver new antimicrobial agents with improved potency. Graphic abstract: [Figure not available: see fulltext.].
5,6-dimethoxy indanone compound as well as preparation method and application thereof
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Paragraph 0022; 0043; 0048, (2019/10/17)
The invention discloses a 5,6-dimethoxy indanone compound as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) by taking 3-hydroxybenzaldehyde as an initial raw material, in the presence of a f
