186201-60-5

Basic information

• Product Name: 2-BENZYL-OCTAHYDRO-CYCLOPENTA[C]PYRROL-4-YLAMINE
• Synonyms: 2-N-BENZYL-OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINE;2-BENZYL-OCTAHYDRO-CYCLOPENTA[C]PYRROL-4-YLAMINE;2-BENZYLOCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINE
• CAS NO: 186201-60-5
• Molecular Formula: C14H20N2
• Molecular Weight: 216.32
• Product Categories: pharmacetical
• Mol File: 186201-60-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-BENZYL-OCTAHYDRO-CYCLOPENTA[C]PYRROL-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-OCTAHYDRO-CYCLOPENTA[C]PYRROL-4-YLAMINE(186201-60-5)
• EPA Substance Registry System: 2-BENZYL-OCTAHYDRO-CYCLOPENTA[C]PYRROL-4-YLAMINE(186201-60-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 186201-60-5(Hazardous Substances Data)

Usage

General Description

2-Benzyl-octahydro-cyclopenta[c]pyrrol-4-ylamine, also known as with the chemical formula C16H23N, is a compound with potential pharmaceutical and therapeutic applications. This chemical is a type of amine containing a cyclic structure, with a benzene ring and an octahydro-cyclopenta[c]pyrrol moiety. It may have potential biological activity due to its structural features, and it could be used in the development of new drugs or therapies. Further research and study are needed to fully understand the potential uses and effects of this chemical compound.

Upstream product

• 1567815-94-4 C₁₈H₂₈N₂OS 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 101046-32-6 (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one 
• 930-30-3 cyclopent-2-enone 
• 1384106-80-2 (R)-N-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl)-2-methylpropane-2-sulfinamide 
• 1384106-78-8 (R,E)-N-((3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)-2-methylpropane-2-sulfinamide 
• 1228029-75-1 (S)-N-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl)-2-methylpropane-2-sulfinamide 
• 1228029-78-4 (3aS,4S,6aR)-2-Benzyloctahydrocyclopenta[c]pyrrol-4-yl methanesulfonate 
• 1228029-77-3 racemic-(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ol 
• 174293-33-5 (3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-one 
• 1228029-79-5 (3aS,4R,6aR)-4-azido-2-benzyloctahydrocyclopenta[c]pyrrole 
• 939033-18-8 C₁₅H₂₁NO₃S 
• 1349980-80-8 (3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ol 
• 122828-28-8 2-benzylhexahydrocyclopenta[C]pyrrole-4-(1H)-one oxime 

Downstream Products

• 1228026-07-0 tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate 
• 1228030-08-7 tert-butyl (3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylcarbamate 
• 1228030-25-8 (3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-amine 
• 1228030-45-2 tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate 
• 1228026-44-5 tert-butyl (methyl)((S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate 
• 1228027-28-8 tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)hexan-2-yl)carbamate 
• 1228027-29-9 tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate 
• 1228027-26-6 tert-butyl (S)-3,3-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-ylcarbamate 
• 1228027-22-2 tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate 
• 1228026-43-4 N-(tert-butoxycarbonyl)-N-methyl-N-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-1-phenylalaninamide 
• 1228027-80-2 N₂-methyl-N₁-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide 
• 1228027-90-4 N₂-methyl-N₁-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide 
• 1228028-03-2 N₂-methyl-N₁-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norleucinamide 
• 1228028-04-3 4-methyl-N₁-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide 

Relevant articles and documents

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres

This Letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free fraction, and modest CNS penetration. Moreover, enantioselective GlyT1 inhibition was observed, within this novel series and a number of other piperidine bioisosteric cores.

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca 2+ channel blockers with analgesic activity

A novel 4-aminocyclopentapyrrolidine series of N-type Ca2+ channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectivity over L-type Ca2+ channels. N-type Ca2+ channel blockade was confirmed using electrophysiological recording techniques. Compound 25 is an N-type Ca 2+ channel blocker that produces antinociception in inflammatory and nociceptive pain models without exhibiting cardiovascular or motor liabilities.

ANTIBACTERIAL AGENTS

Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment bacterial infections in mammals, particularly humans, are disclosed herein.