186203-11-2Relevant academic research and scientific papers
Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4- trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones
Fukui, Hideto,Shibata, Tetsuo,Naito, Takanobu,Nakano, Jun,Maejima, Tetsuro,Senda, Hisato,Iwatani, Wakao,Tatsumi, Yoshiyuki,Suda, Masahiro,Arika, Tadashi
, p. 2833 - 2838 (1998)
The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R,4S)3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphyrococcus aureus and low side effect potential.
