Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4- trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones

DOI: 10.1016/S0960-894X(98)00514-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2833 - 2838 (1998)

Update date:2022-08-02

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Authors:

Fukui, Hideto

Shibata, Tetsuo

Naito, Takanobu

Nakano, Jun

Maejima, Tetsuro

Senda, Hisato

Iwatani, Wakao

Tatsumi, Yoshiyuki

Suda, Masahiro

Arika, Tadashi

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Article abstract of DOI:10.1016/S0960-894X(98)00514-9

The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R,4S)3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphyrococcus aureus and low side effect potential.

Full text of DOI:10.1016/S0960-894X(98)00514-9

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