186246-68-4Relevant academic research and scientific papers
Syntheses of daidzein-7-yl β-D-glucopyranosiduronic acid and daidzein-4′,7-yl di-β-D-glucopyranosiduronic acid
Needs, Paul W.,Williamson, Gary
, p. 511 - 515 (2001)
Syntheses of the title compounds - commonly known as 'daidzein 7-glucuronide' and 'daidzein 4′,7-diglucuronide' - are described. Selective 7-deacetylation of 4′,7-di-O-acetyldaidzein is employed.
Study on the synthesis, antioxidant properties, and self-assembly of carotenoid–flavonoid conjugates
Línzembold, Ildikó,Czett, Dalma,B?ddi, Katalin,Kurtán, Tibor,Király, Sándor Balázs,Gulyás-Fekete, Gergely,Takátsy, Anikó,Lóránd, Tamás,Deli, József,Agócs, Attila,Nagy, Veronika
, (2020/02/11)
Flavonoids and carotenoids possess beneficial physiological effects, such as high antioxidant capacity, anticarcinogenic, immunomodulatory, and anti-inflammatory properties, as well as protective effects against UV light. The covalent coupling of hydropho
Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate
Wang, Jiawang,Zhao, Jianhong,Gong, Hegui
, p. 10180 - 10183 (2017/09/23)
This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.
Phosphoramidate protides of five flavones and their antiproliferative activity against HepG2 and L-O2 cell lines
Li, Yue-Qing,Yang, Fei,Wang, Liu,Cao, Zhi,Han, Tian-Jiao,Duan, Zhe-Ang,Li, Zhen,Zhao, Wei-Jie
, p. 196 - 208 (2016/05/02)
A series of flavone-7-phosphoramidate derivatives were synthesized and tested for their antiproliferative activity in vitro against human hepatoma cell line HepG2 and human normal hepatic cell line L-O2. Compound 8d, 16d and 17d, incorporating the amino acid alanine, exhibited high inhibitory activity on HepG2 cell line with IC50 values of 9.0 μmol/L, 5.5 μmol/L and 6.6 μmol/L. The introduction of acyl groups played a pivotal role in the selective inhibition toward human hepatoma HepG2 cells, except for compound 8a, 9a and 16b. Compound 8d, 16d and 17d could significantly induce G2/M arrest in HepG2 cells. Specially, Compound 16d could lead early apoptosis in HepG2 cells.
Facile synthesis of flavonoid 7-O-glycosides
Li, Ming,Han, Xiuwen,Yu, Biao
, p. 6842 - 6845 (2007/10/03)
Highly regioselective removal of the 7-O-acyl groups of the peracylated flavones, isoflavones, and flavonols (PhSH, imidazole, NMP) followed by effective glycosylation with glycosyl trifluoroacetimidates (BF 3·Et2O) and cautious deprotection of the acyl groups under basic conditions afforded the desired 7-O-flavonoid glycosides in satisfactory yields.
