3682-01-7

Basic information

• Product Name: Daidzein diacetate
• Synonyms: Daidzein diacetate;4',7-Diacetyl-O-isoflavone;4',7-Dihydroxy-isoflavone Diacetate;7-(Acetyloxy)-3-[4-(acetyloxy)phenyl]-4H-1-benzopyran-4-one;7,4'-Diacetoxyisoflavone
• CAS NO: 3682-01-7
• Molecular Formula: C₁₉H₁₄O₆
• Molecular Weight: 338.31
• Product Categories: Inhibitors;Tyrosine Kinase Inhibitors
• Mol File: 3682-01-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Solubility: Dimethyl sulfoxide, Hot Methanol
• CAS DataBase Reference: Daidzein diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Daidzein diacetate(3682-01-7)
• EPA Substance Registry System: Daidzein diacetate(3682-01-7)

Safety Data

• Hazardous Substances Data: 3682-01-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Protected Daidzein (D103500).

Upstream product

• 486-66-8 daidzein 
• 108-24-7 acetic anhydride 
• 552-66-9 daidzin 
• 156-38-7 4-hydroxyphenylacetate 
• 108-46-3 recorcinol 
• 15485-80-0 7-hydroxy-3-(4-nitrophenyl)-4H-chromen-4-one 
• 77316-78-0 7-hydroxy-3-(4-aminophenyl)-4H-benzopyran-4-one 
• 17720-60-4 2,4,4'-trihydroxy deoxybenzoin 

Downstream Products

• 81267-11-0 4',7-diacetoxyisoflavan-4-one 
• 457655-68-4 O,O'-diacetyl tetrahydrodaidzein 
• 81267-09-6 trans-4',7-diacetoxyisoflavan-4-ol 
• 81267-09-6 cis-4',7-diacetoxyisoflavan-4-ol 
• 188881-57-4 7-(6-bromohexyloxy)-3-(4-hydroxyphenyl)-4H-chromen-4-one 
• 531-95-3 equol 
• 13401-41-7 7-acetoxy-3-(4-acetoxy-phenyl)-chroman 
• 221054-79-1 (+)-Equol 

Relevant articles and documents

Study on the synthesis, antioxidant properties, and self-assembly of carotenoid–flavonoid conjugates

Flavonoids and carotenoids possess beneficial physiological effects, such as high antioxidant capacity, anticarcinogenic, immunomodulatory, and anti-inflammatory properties, as well as protective effects against UV light. The covalent coupling of hydropho

SYNTHESIS OF ISOFLAVANES AND INTERMEDIATES THEREOF

Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

Phosphoramidate protides of five flavones and their antiproliferative activity against HepG2 and L-O2 cell lines

A series of flavone-7-phosphoramidate derivatives were synthesized and tested for their antiproliferative activity in vitro against human hepatoma cell line HepG2 and human normal hepatic cell line L-O2. Compound 8d, 16d and 17d, incorporating the amino acid alanine, exhibited high inhibitory activity on HepG2 cell line with IC50 values of 9.0 μmol/L, 5.5 μmol/L and 6.6 μmol/L. The introduction of acyl groups played a pivotal role in the selective inhibition toward human hepatoma HepG2 cells, except for compound 8a, 9a and 16b. Compound 8d, 16d and 17d could significantly induce G2/M arrest in HepG2 cells. Specially, Compound 16d could lead early apoptosis in HepG2 cells.