186293-54-9

Basic information

• Product Name: Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)-
• Synonyms: Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)-;(2R)-2-(Chloromethyl)-4-(phenylmethyl)morpholine;Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (R)-
• CAS NO: 186293-54-9
• Molecular Formula: C12H16ClNO
• Molecular Weight: 226
• Mol File: 186293-54-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 314.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.132±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.09±0.10(Predicted)
• CAS DataBase Reference: Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)-(186293-54-9)
• EPA Substance Registry System: Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)-(186293-54-9)

Safety Data

• Hazardous Substances Data: 186293-54-9(Hazardous Substances Data)

Usage

Description

Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)is a chiral morpholine derivative with the molecular formula C13H18ClNO. It features a chloromethyl and phenylmethyl group, and the (2R)-enantiomer exhibits a specific stereochemical configuration. Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)is primarily utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and may also find applications in organic synthesis and chemical research.

Uses

Used in Pharmaceutical Industry:
Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural features, contributing to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)serves as an essential intermediate in the production of agrochemicals, aiding in the creation of effective pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Organic Synthesis:
Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)is employed as a versatile building block in organic synthesis, enabling the construction of complex organic molecules for a wide range of applications, including the development of new materials and compounds.
Used in Chemical Research:
Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)is utilized in chemical research to explore its properties, reactivity, and potential applications, furthering the understanding of chiral morpholine derivatives and their role in various chemical processes.
It is crucial to handle Morpholine, 2-(chloromethyl)-4-(phenylmethyl)-, (2R)with care due to its potential health hazards, and it should be used in a controlled laboratory setting to ensure safety.

Upstream product

• 100-52-7 benzaldehyde 
• 174560-84-0 1-chloro-3-[(2-hydroxyethyl)(phenylmethyl)amino]-2-propanol 
• 104-63-2 N-Benzylethanolamine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 146944-34-5 (4-benzylmorpholin-2-ylmethyl)carbamic acid tert-butyl ester 
• 173341-02-1 N-(morpholin-2-ylmethyl)carbamic acid tert-butyl ester 
• 128208-00-4 2-(pyrrolidin-1-ylmethyl)morpholine 
• 135065-69-9 tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate 
• 156121-11-8 4-benzyl-2-(ethoxymethyl)morpholine 
• 46346-82-1 2-[phenoxymethyl]-morpholine 
• 156121-15-2 2-(methoxymethyl)morpholine 
• 103003-01-6 morpholin-2-ylmethanol 
• 143804-53-9 4-benzyl-2-(methoxymethyl)morpholine 
• 650579-38-7 1,1-dimethylethyl 2-(chloromethyl)morpholine-2-carboxylate 
• 1615654-24-4 2-[4-(morpholin-2-ylmethoxy)phenyl]ethanol hydrochloride 
• 1615654-68-6 2-[4-[(4-benzylmorpholin-2-yl)methoxy]phenyl]ethanol 
• 1589517-84-9 4-benzyl-2-((4'-fluorophenoxy)methyl)morpholine 
• 1589517-95-2 2-(((4[18F]Fluoro-5-fluorobiphen)-2-yl)oxymethyl)morpholine 

Relevant articles and documents

Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer

The enzyme butyrylcholinesterase (BChE) represents a promising target for imaging probes to potentially enable early diagnosis of neurodegenerative diseases like Alzheimer's disease (AD) and to monitor disease progression in some forms of cancer. In this study, we present the design, facile synthesis, in vitro and preliminary ex vivo and in vivo evaluation of a morpholine-based, selective inhibitor of human BChE as a positron emission tomography (PET) tracer with a pseudo-irreversible binding mode. We demonstrate a novel protecting group strategy for 18F radiolabeling of carbamate precursors and show that the inhibitory potency as well as kinetic properties of our unlabeled reference compound were retained in comparison to the parent compound. In particular, the prolonged duration of enzyme inhibition of such a morpholinocarbamate motivated us to design a PET tracer, possibly enabling a precise mapping of BChE distribution.

Fast and efficient 18F-labeling by [18F]fluorophenylazocarboxylic esters

Introduction of [18F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95% (85(±10) %). For labeling purposes, the resulting 18F-substituted azoester can be further converted in radical-arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides.

A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.