186302-80-7Relevant academic research and scientific papers
Some reactions of 4-ethoxycarbonyl - And 4-chlorocarbonyl-3-chloro-5,6 diphenylpyridazines, synthesis of some fused pyridazines
Shalaby
, p. 401 - 412 (2007/10/03)
REACTION of compound 1 with benzhydrazide in refluxing 1-butanol yielded triazolo[4,3-b] pyridazine 2. On treatment of 1 with sodium azide in dimethylformamide produced pyrazolopyridazine 3. However, reaction of 1 with o-aminothiophenol gave thiazepinopyridazine 4. While, treatment of 1 with 2-aminoethanol and 2-mercaptoethanol gave the pyridazine derivatives 5 and 6. respectively. Moreover, treatment of 1 and 9 or 10 with ethylenediamine afforded pyridazino[4,3-f]diazepines 7 and 11, respectively. Also, compound 9 reacted with 2-aminoethanol forming pyridazino[4,3-f]oxazepine derivative 12. While reaction of 9 or 10 with o-phenylenediamine, o-aminophenol and o-aminothiophenol produced diazepino-, oxazepino- and thiazepinopyridazine derivatives 13-15, respectively. Hydrazinolysis of 9 afforded the pyrazolopyridazine 16. Grignard reaction on 13 using phenylmagnesium bromide and benzylmagnesium chloride gave pyridazinodiazepine derivatives 17 and 18, respectively. However, sulfuration of 11 and 16 with phosphorus pentasulfide gave the thionated products 19 and 20, respectively. Compound 20 was trapped by methylation with methyliodide to give 21.
Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
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, (2008/06/13)
The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high association constant to the carrier molecule. The invention also relates to medicaments containing these ligand compounds and to diagnostic kits.
