186320-19-4

Usage

Uses

Used in Organic Chemistry and Biochemistry:
FMOC-DL-BETA-AIB-OH is used as a protecting group for amino acids during peptide synthesis, ensuring selective deprotection and modification of the AIB residue.
Used in Peptide Synthesis:
FMOC-DL-BETA-AIB-OH is used as a building block for the preparation of various functionalized peptides, contributing to the development of complex peptide structures.
Used in Peptidomimetics Preparation:
FMOC-DL-BETA-AIB-OH is used as a component in the synthesis of peptidomimetics, which are compounds that mimic the biological activity of peptides.
Used in Protein Structure and Function Studies:
FMOC-DL-BETA-AIB-OH is used as a research tool in the study of protein structure and function, aiding in the understanding of protein dynamics and interactions.
Used in Drug Development:
FMOC-DL-BETA-AIB-OH is utilized in the development of new drugs, potentially contributing to the discovery of novel therapeutic agents.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28267-25-6 (RS)-2-(aminomethyl)propanoic acid hydrochloride 
• 10569-72-9 DL-3-aminoisobutyric acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Relevant academic research and scientific papers

METHODS FOR DETECTING RENAL DISEASE

Methods for determining renal function in an animal subject, the method including measuring the concentration of β-aminoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.

A new enantioselective synthesis of β-amino acids

Enantioselective hydrogenation of some α,β-unsaturated nitriles and their corresponding methyl esters bearing a phthalimidomethyl substituent at the α-carbon using Rh-DuPHOS catalysts afforded β-amino acid precursors with modest e.e.s of up to 48%. Hydrogenation of the α,β-unsaturated methyl esters using a Ru-BINAP catalyst gave higher e.e.s of up to 84%. Method development for the determination of the enantiomeric excesses of these derivatives using chiral HPLC is also reported.