3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid

Base Information

• Chemical Name: 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid
• CAS No.: 186320-19-4
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID00394532
• Nikkaji Number: J1.619.041A
• Mol file: 186320-19-4.mol

Synonyms:186320-19-4;3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid;fmoc-dl-beta-aminoisobutyric acid;3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methylpropanoic acid;3-(Fmoc-amino)-2-methylpropanoic acid;3-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-2-METHYLPROPANOIC ACID;MFCD03788584;MFCD04040043;FMOC-S-3-AMINOISOBUTYRIC ACID;Fmoc-(R)-3-Amino-2-methylpropanoic acid;Fmoc-(S)-3-Amino-2-methylpropanoic acid;(R)-3-(Fmoc-amino)-2-methylpropanoic Acid;(S)-3-(Fmoc-amino)-2-methylpropanoic Acid;Fmoc-DL-beta-Aib-OH;SCHEMBL60494;Fmoc-S-3-Aminoisobutyricacid;Fmoc-DL-3-Aminoisobutyric acid;SCHEMBL15727228;DTXSID00394532;BMUDOYSTGJHGNI-UHFFFAOYSA-N;MFCD01863213;AKOS012614302;Propanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-;AB16062;AB17476;SY074023;SY074126;CS-0217666;EN300-81341;Fmoc-DL-beta-aminoisobutyric acid, AldrichCPR;Z1123720112;3-[[(9H-Fluorene-9-yl)methoxycarbonyl]amino]-2-methylpropanoic acid;DL-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid

Chemical Property of 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid

Chemical Property:

• Boiling Point: 555.265 °C at 760 mmHg
• Flash Point: 289.614 °C
• PSA: 75.63000
• Density: 1.255 g/cm³
• LogP: 3.63670
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 325.13140809
• Heavy Atom Count: 24
• Complexity: 444

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-DL-beta-aminoisobutyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C(=O)O

Technology Process of 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid

There total 2 articles about 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (RS)-2-(aminomethyl)propanoic acid hydrochloride (28267-25-6,925704-45-6,132605-98-2) → 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-methylpropanoic acid (186320-19-4)

Guidance literature:

With sodium carbonate; In water; acetone; at 4 - 20 ℃; for 4.33h;

DOI:10.1016/S0957-4166(01)00097-0

Reference yield:

DL-3-aminoisobutyric acid (10569-72-9) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-methylpropanoic acid (186320-19-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

Nα-(tert-butoxycarbonyl)-1-methyl-L-tryptophan (144599-95-1) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + N-(9-fluorenylmethoxycarbonyl)-D-alanine (35661-38-2,35661-39-3,79990-15-1,136132-75-7) + (2S,3R)-Fmoc-O-benzyl-threonine (117872-75-0) + 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-methylpropanoic acid (186320-19-4) → C69H107N11O16

Guidance literature:

N-(9-fluorenylmethoxycarbonyl)-D-alanine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

N^α-(tert-butoxycarbonyl)-1-methyl-L-tryptophan; Fmoc-Val-OH; Fmoc-Leu-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; (2S,3R)-Fmoc-O-benzyl-threonine; 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-methylpropanoic acid; Further stages;

DOI:10.1039/c8ob02867b

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(RS)-2-(aminomethyl)propanoic acid hydrochloride

DL-3-aminoisobutyric acid

(fluorenylmethoxy)carbonyl chloride

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