186342-07-4

Upstream product

• 66224-66-6 adenine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 19255-48-2 9-(2-chloroethyl)adenine 

Downstream Products

• 186342-08-5 9-N-vinyl-6-N-dimethoxytrityladenine 
• 199522-02-6 [9-(2-Chloro-ethyl)-9H-purin-6-yl]-(9-phenyl-9H-xanthen-9-yl)-amine 
• 199522-03-7 (9-Phenyl-9H-xanthen-9-yl)-(9-vinyl-9H-purin-6-yl)-amine 

Relevant academic research and scientific papers

A novel class of 4'-aza analogues of 2',3'-dideoxynucleosides as potential anti-HIV drugs

The 1,3 dipolar cycloaddition approach represents the most valuable strategy for the preparation of isoxazolidine nucleosides. The latter posses more conformational degrees of freedom than the corresponding dideoxyribosides. Side reactions due to the presence of formaldehyde in the reaction media can be avoided by proper derivatization of the vinyl- nucleobase.

Synthesis of two 6-N-protected 9-N-vinyladenines AS dipolarophiles in the synthesis of modified nucleosides

A new class of potential antiviral drugs is represented by isoxazolidine nucleosides. The paper reports on the synthesis of protected adenines useful as dipolarophiles in the preparation of analogues of dideoxyadenosine by 1,3-dipolar cycloaddition processes.