A novel class of 4'-aza analogues of 2',3'-dideoxynucleosides as potential anti-HIV drugs

Article abstract of DOI:10.1080/07328319708006219

The 1,3 dipolar cycloaddition approach represents the most valuable strategy for the preparation of isoxazolidine nucleosides. The latter posses more conformational degrees of freedom than the corresponding dideoxyribosides. Side reactions due to the presence of formaldehyde in the reaction media can be avoided by proper derivatization of the vinyl- nucleobase.

Full text of DOI:10.1080/07328319708006219

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Nucleosides and Nucleotides
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A Novel Class of 4′-Aza Analogues of
2′,3′-Dideoxynucleosides as Potential
Anti-HIV Drugs
Antonella Leggio a , Angelo Liguori a , Antonio Procopio a , Carlo
Siciliano a & Giovanni Sindona a
a Dipartimento di Chimica, Università della Calabria, I-87030,
Arcavacata di Rende, CS, Italy
Version of record first published: 16 Aug 2006.
To cite this article: Antonella Leggio , Angelo Liguori , Antonio Procopio , Carlo Siciliano &
Giovanni Sindona (1997): A Novel Class of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides as
Potential Anti-HIV Drugs, Nucleosides and Nucleotides, 16:7-9, 1515-1518
To link to this article: http://dx.doi.org/10.1080/07328319708006219
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