186350-77-6

Upstream product

• 2270-59-9 1-bromo-4-methylpent-3-ene 
• 25309-65-3 4-ethylbenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 
• 186350-79-8 4-[4-(1,3-dioxolan-2-yl)but-2-yl]benzonitrile 
• 101478-65-3 4-[3-(1,3-dioxolan-2-yl)prop-1-yl]benzonitrile 
• 104-85-8 para-methylbenzonitrile 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 186350-82-3 4-(1-methyl-4-oxobutyl)benzonitrile 

Relevant academic research and scientific papers

Radical-Based C?C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines

We report herein that 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) can directly reach an electronically excited state upon light absorption and trigger the generation of C(sp3)-centered radicals without the need for an external photocatalyst. Selective excitation with a violet-light-emitting diode turns alkyl-DHPs into strong reducing agents that can activate reagents through single-electron transfer manifolds while undergoing homolytic cleavage to generate radicals. We used this photochemical dual-reactivity profile to trigger radical-based carbon–carbon bond-forming processes, including nickel-catalyzed cross-coupling reactions.

Synthesis of rac-ar-curcumen-15-al

Starting from p-tolunitrile (4) via alkylation with the bromo-acetal 12 (→ 8), and with MeI (→ 9), hydrolysis to 10, Wittig reaction (→ 7) and DIBAH reduction, the rac-ar-curcumen-15-al (2) was obtained. The cumin-like, citrus odor of rac-2 is similar to that of the isolated (-)-2. VCH Verlagsgesellschaft mbH, 1997.