186352-43-2

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 186352-42-1 N-formyl-6-[3-(2-hydroxyphenyl)propyl]-1,2,3,4-tetrahydropyridine 
• 1028285-96-2 tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine 
• 1745-81-9 o-Allylphenol 
• 151950-83-3 3-<2-<(tert-butyldimethylsilyl)oxy>phenyl>-1-iodopropane 
• 327155-45-3 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol 
• 151950-94-6 1-tert-butyldimethylsilyloxy-2-(2-propenyl)benzene 

Relevant academic research and scientific papers

Intramolecular Enantioselective Palladium-Catalyzed Heck Arylation of Cyclic Enamides

Palladium-catalyzed intramolecular cyclization of N-formyl-6--1,2,3,4-tetrahydropyridine (1a) and N-formyl-6--1,2,3,4-tetrahydropyridine (1b) in the presence of AsPh3 resulted in formation of the spiro compounds N-formyl-3,3',4,4'-tetrahydrospiro (2a) and N-formyl-3',4'-dihydrospiro (2b), respectively, and in the presence of PPh3 and TlOAc in the spiro compounds N-formyl-3,4,5',6'-tetrahydrospiro (3a) and N-formyl-5',6'-dihydrospiro (3b), respectively.Cyclization of N-formyl-6-(3-phenyl>propyl)-1,2,3,4-tetrahydropyridine (7) in presence of a chiral (phosphinoaryl)oxazoline ((S)-8) resulted in formation of (R)-3a and (R)-N-formyl-1',3,4,6'-tetrahydrospiro ((R)-6a) in high enantiomeric excesses, 87 percent and >99percent, respectively, and in good yield.The oxazoline ligand (S)-8 furnished higher enantiomeric excesses and improved regioselectivities than (R)-BINAP.